Hyperpolarised MR technologies and molecular probes as alternatives for conventional metal-containing contrast agents for MRI examinations

Project description

Safer diagnostic agents for MRI

Contrast-enhanced magnetic resonance imaging (MRI) is an important and versatile medical diagnostics technique, particularly for cancers. Warnings have been issued against Gadolinium (Gd)-based contrast agents (GBCAs), which are routinely employed during MRI diagnostic procedures, due to health concerns about Gd accumulation in the human body. The EU-funded AlternativesToGd project aims to develop metal-free hyperpolarised (HP) metabolic CAs to enable molecular imaging and monitor enzymatic conversions with very high sensitivity. A major challenge for researchers is overcoming the short lifetime of HP states in these CAs. The team will investigate three ground-breaking HP techniques to maximise HP lifetime and achieve unprecedented sensitivity in contrast-enhanced MRI diagnostics with CAs that are safe, non-toxic and completely eliminated from the body after the procedure.

Field of science

• /engineering and technology/medical engineering/diagnostic imaging/magnetic resonance imaging
• /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds

Programme(s)

• H2020-EU.1.2.1. - FET Open

Topic(s)

• FETOPEN-01-2018-2019-2020 - FET-Open Challenging Current Thinking

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

HADASSAH MEDICAL ORGANIZATION

Address

N/a
91120 Jerusalem
Israel

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 346 250

Participants (9)

UNIVERSITA DEGLI STUDI DI TORINO

Italy

EU contribution

€ 270 000

Address

Via Giuseppe Verdi 8
10124 Torino

Activity type

Higher or Secondary Education Establishments

DANMARKS TEKNISKE UNIVERSITET

Denmark

EU contribution

€ 339 975

Address

Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby

Activity type

Higher or Secondary Education Establishments

UNIVERSITAET ULM

Germany

EU contribution

€ 179 687,50

Address

Helmholtzstrasse 16
89081 Ulm

Activity type

Higher or Secondary Education Establishments

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU contribution

€ 339 985

Address

Wellington Square University Offices
OX1 2JD Oxford

Activity type

Higher or Secondary Education Establishments

RS2D

France

EU contribution

€ 450 750

Address

13 Rue Vauban
67450 Mundolsheim

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU contribution

€ 326 250

Address

Hofgartenstrasse 8
80539 Muenchen

Activity type

Research Organisations

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE

United Kingdom

EU contribution

€ 332 226,25

Address

Trinity Lane The Old Schools
CB2 1TN Cambridge

Activity type

Higher or Secondary Education Establishments

EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG

Austria

EU contribution

€ 300 625

Address

Am Gestade 1
1010 Wien

Activity type

Research Organisations

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Italy

EU contribution

€ 180 207,50

Address

Via Morego 30
16163 Genova

Activity type

Research Organisations