Skip to main content

Hyperpolarised MR technologies and molecular probes as alternatives for conventional metal-containing contrast agents for MRI examinations

Project description

Safer diagnostic agents for MRI

Contrast-enhanced magnetic resonance imaging (MRI) is an important and versatile medical diagnostics technique, particularly for cancers. Warnings have been issued against Gadolinium (Gd)-based contrast agents (GBCAs), which are routinely employed during MRI diagnostic procedures, due to health concerns about Gd accumulation in the human body. The EU-funded AlternativesToGd project aims to develop metal-free hyperpolarised (HP) metabolic CAs to enable molecular imaging and monitor enzymatic conversions with very high sensitivity. A major challenge for researchers is overcoming the short lifetime of HP states in these CAs. The team will investigate three ground-breaking HP techniques to maximise HP lifetime and achieve unprecedented sensitivity in contrast-enhanced MRI diagnostics with CAs that are safe, non-toxic and completely eliminated from the body after the procedure.

Field of science

  • /engineering and technology/medical engineering/diagnostic imaging/magnetic resonance imaging
  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds

Call for proposal

H2020-FETOPEN-2018-2019-2020-01
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

HADASSAH MEDICAL ORGANIZATION
Address
N/a
91120 Jerusalem
Israel
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 346 250

Participants (9)

UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 270 000
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 339 975
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET ULM
Germany
EU contribution
€ 179 687,50
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 339 985
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
RS2D
France
EU contribution
€ 450 750
Address
13 Rue Vauban
67450 Mundolsheim
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 326 250
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 332 226,25
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
EIBIR GEMEINNUTZIGE GMBH ZUR FORDERUNG DER ERFORSCHUNG DER BIOMEDIZINISCHEN BILDGEBUNG
Austria
EU contribution
€ 300 625
Address
Am Gestade 1
1010 Wien
Activity type
Research Organisations
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Italy
EU contribution
€ 180 207,50
Address
Via Morego 30
16163 Genova
Activity type
Research Organisations