CORDIS
EU research results

CORDIS

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Conformational Shift Inducers (CSI): An atomistic level investigation of Aurora kinase A (AurkA)–MYC interaction and its distortion by CSI compounds

Project information

Grant agreement ID: 839230

Status

Ongoing project

  • Start date

    1 June 2019

  • End date

    31 May 2021

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 174 806,40

  • EU contribution

    € 174 806,40

Coordinated by:

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany

Project description

English EN

Research to render solid tumours to a not-so-solid state

Cancer treatment has advanced in leaps and bounds in general but effective treatments for solid tumours are lacking. The oncoprotein MYC is implicated in the emergence and maintenance of solid tumours but until recently researchers believed the protein was resistant to drugs. The binding of this oncogene to Aurora kinase A (AurkA) protects it from proteasomal degradation but little is known about this process. The EU-funded CSI AurkA-MYC project aims to understand the AurkA-MYC interaction on the molecular level. Their goal is to determine potential conformational shift inducers (CSIs) that can block AurkA-MYC binding to facilitate MYC degradation and solid tumour treatment for better patient outcomes.

Coordinator

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Address

Geschwister-Scholl-Platz
72074 Tuebingen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 174 806,40

Project information

Grant agreement ID: 839230

Status

Ongoing project

  • Start date

    1 June 2019

  • End date

    31 May 2021

Funded under:

H2020-EU.1.3.2.

  • Overall budget:

    € 174 806,40

  • EU contribution

    € 174 806,40

Coordinated by:

EBERHARD KARLS UNIVERSITAET TUEBINGEN

Germany