Skip to main content

A Cost-Effective Photonics-based Device for Early Prediction, Monitoring and Management of Diabetic Foot Ulcers

Objective

Early prediction and management of Diabetic Foot Ulcers (DFUs) is an important health factor of Europe. Recent clinical trials have concluded that NIR sensing captures oxy(deoxy)haemoglobin (HbO2, Hb) and peripheral/ tissue oxygen saturations (StO2, SpO2), thermal Infrared-IR detects hyperthermia, among Regions of Interest (ROIs) and Mid-IR contains rich information about the proteomics, lipidomics and metabolomics (e.g., glucose). All these medical indices are important factors for early prediction of DFU.
Current medical approaches are i) invasive (e.g., skin lesion biopsy), ii) requires consumables, and iii) being operated by certified physicians (e.g., ultrasound and/or biopsy).
PHOOTONICS aims at developing a non-invasive, reliable and cost-effective photonics-driven device for DFU monitoring and management which can be applied for wide use. The project supports two versions: (i) the PHOOTONICS In-Home, used for DFU monitoring by patients and (ii) the PHOOTONICS PRO operated by physicians.
Reliability is achieved by optimizing i) passive Hyperspectral (HIS) NIR photo-detector, with an active tuneable diode illuminator for detecting SpO2/StO2, HbO2 and Hb, ii) a thermal-IR sensor of detecting hyperthermia/hypothermia distributions in ROIs and iii) a passive Mid-IR sensing with a Quantum Cascade Laser (QCL) optimized to capture additional tissue attributes such as proteomics (elastin, collagen) and metabolomics (glucose). Cost-effectiveness is achieved by introducing i) targeted photonics technologies for DFU, ii) implementing advanced signal processing/learning algorithms to increase the discrimination accuracy while maintaining hardware cost-benefit, (iii) developing a user-friendly framework operated by non-certified physicians, and even by patients (for the In-Home version), and (iv) minimising operational cost with our non-invasive device. Clinical studies are performed to validate the reliability of the new cost-effective device in real-life settings.

Field of science

  • /social sciences/sociology/social problems/ageism
  • /natural sciences/physical sciences/acoustics/ultrasound
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/proteomics
  • /natural sciences/physical sciences/optics/laser physics

Call for proposal

H2020-ICT-2019-2
See other projects for this call

Funding Scheme

IA - Innovation action

Coordinator

UAB METIS BALTIC
Address
Jogailos G 4
01116 Vilnius
Lithuania
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 381 937,50

Participants (9)

INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM
Belgium
EU contribution
€ 397 281,25
Address
Kapeldreef 75
3001 Leuven
Activity type
Research Organisations
ALPES LASERS SA
Switzerland
EU contribution
€ 702 187,50
Address
Avenue Des Paquiers 1
2072 Saint-blaise
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
QUEST PHOTONIC DEVICES BV
Netherlands
EU contribution
€ 646 625
Address
Industrieweg 41
1775 PW Middenmeer
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EXUS SOFTWARE MONOPROSOPI ETAIRIA PERIORISMENIS EVTHINIS
Greece
EU contribution
€ 318 500
Address
73-75 Mesogion Avenue
11526 Athens
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA
Greece
EU contribution
€ 403 750
Address
Heroon Polytechniou 9 Zographou Campus
15780 Athina
Activity type
Higher or Secondary Education Establishments
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 273 750
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
EU contribution
€ 262 500
Address
6 Christou Lada Str
10561 Athina
Activity type
Higher or Secondary Education Establishments
UNIVERSITATEA DE MEDICINA SI FARMACIE VICTOR BABES TIMISOARA
Romania
EU contribution
€ 161 250
Address
Piata Eftimie Murgu 2A
300041 Timisoara
Activity type
Higher or Secondary Education Establishments
TIME.LEX
Belgium
EU contribution
€ 139 125
Address
Joseph Stevensstraat 7
1000 Brussel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)