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Adaptive Immunity in Human Atherosclerosis: Understanding its Cellular Basis to Define Novel Immunomodulatory Therapies

Project description

Stopping traitors before they turn could provide new therapies for atherosclerosis

Atherosclerosis is a chronic arterial disease characterised by the build-up of lipid-containing materials (plaques) that can clog arteries. Over the last few decades, evidence has shown that immunity-associated chronic inflammation can trigger events leading to severe atherosclerotic cardiovascular disease. Some cells in the immune system recognise a protein in low-density lipoprotein (LDL) cholesterol. It appears that they normally serve a protective function against atherosclerosis but they can become pathogenic during the course of the disease. ANIMATE is looking for evidence of this process using a variety of techniques and systems. Characterising the immune cells' changing functions in time and space could point to novel mechanisms to prevent the protective cell pools from changing their focus.

Host institution

UNIVERSITAETSKLINIKUM FREIBURG
Net EU contribution
€ 1 499 946,00
Address
Hugstetter Strasse 49
79106 Freiburg
Germany

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Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 499 946,00

Beneficiaries (1)

UNIVERSITAETSKLINIKUM FREIBURG
Germany
Net EU contribution
€ 1 499 946,00
Address
Hugstetter Strasse 49
79106 Freiburg

See on map

Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 499 946,00