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Adaptive Immunity in Human Atherosclerosis: Understanding its Cellular Basis to Define Novel Immunomodulatory Therapies

Project description

Stopping traitors before they turn could provide new therapies for atherosclerosis

Atherosclerosis is a chronic arterial disease characterised by the build-up of lipid-containing materials (plaques) that can clog arteries. Over the last few decades, evidence has shown that immunity-associated chronic inflammation can trigger events leading to severe atherosclerotic cardiovascular disease. Some cells in the immune system recognise a protein in low-density lipoprotein (LDL) cholesterol. It appears that they normally serve a protective function against atherosclerosis but they can become pathogenic during the course of the disease. ANIMATE is looking for evidence of this process using a variety of techniques and systems. Characterising the immune cells' changing functions in time and space could point to novel mechanisms to prevent the protective cell pools from changing their focus.

Field of science

  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases/arteriosclerosis

Call for proposal

ERC-2019-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

UNIVERSITAETSKLINIKUM FREIBURG
Address
Hugstetter Strasse 49
79106 Freiburg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 499 946

Beneficiaries (1)

UNIVERSITAETSKLINIKUM FREIBURG
Germany
EU contribution
€ 1 499 946
Address
Hugstetter Strasse 49
79106 Freiburg
Activity type
Higher or Secondary Education Establishments