Stopping traitors before they turn could provide new therapies for atherosclerosis
Atherosclerosis is a chronic arterial disease characterised by the build-up of lipid-containing materials (plaques) that can clog arteries. Over the last few decades, evidence has shown that immunity-associated chronic inflammation can trigger events leading to severe atherosclerotic cardiovascular disease. Some cells in the immune system recognise a protein in low-density lipoprotein (LDL) cholesterol. It appears that they normally serve a protective function against atherosclerosis but they can become pathogenic during the course of the disease. ANIMATE is looking for evidence of this process using a variety of techniques and systems. Characterising the immune cells' changing functions in time and space could point to novel mechanisms to prevent the protective cell pools from changing their focus.
Field of science
- /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases/arteriosclerosis
Call for proposal
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Funding SchemeERC-STG - Starting Grant