Novel fluorescent drug markers for in vivo imaging
Preclinical and clinical phases in drug discovery would greatly benefit from accurate information about drug distribution. In terms of safety, fluorescent imaging is much better than radioactive markers used in positron emission tomography. However, current fluorescent markers are large entities with positive or negative charge that could change drug properties. This EU-funded project involves four academic and two industrial interdisciplinary teams that aim to develop non-biased red and near infrared fluorescent dyes for in vivo imaging that do not affect the properties of labelled drugs. Developed dyes will be tested using representative known drugs for monitoring and analysis of their distribution in vitro and in vivo.
Call for proposal
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