CORDIS
EU research results

CORDIS

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Molecular Structure and Engineering of Synaptic Organizer Proteins in Health and Disease

Project information

Grant agreement ID: 850820

Status

Ongoing project

  • Start date

    1 March 2020

  • End date

    28 February 2025

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 499 903

  • EU contribution

    € 1 499 903

Hosted by:

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

Project description

English EN

Engineered proteins for synapse repair

Synapses are the cellular junctions that enable communication between neuronal cells. Some synaptic proteins act as structural and functional organisers, mediating synapse formation and differentiation. The idea behind this project is to apply knowledge of how these proteins function to restore damaged synapses that are a result of neurodegeneration. This EU-funded project will generate detailed molecular structures of synaptic protein complexes to decipher their function, using structural biology techniques. The ultimate goal of the project is then to use this knowledge to create engineered variants of these synaptic organiser proteins, and test them for restoring neuronal function in animal models of Alzheimer’s disease where synaptic function is disrupted.

Host institution

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

Address

Rue Michel Ange 3
75794 Paris

France

Activity type

Research Organisations

EU Contribution

€ 1 499 903

Beneficiaries (1)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 1 499 903

Project information

Grant agreement ID: 850820

Status

Ongoing project

  • Start date

    1 March 2020

  • End date

    28 February 2025

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 499 903

  • EU contribution

    € 1 499 903

Hosted by:

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France