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Endosomal control of local protein synthesis in axons

Project description

Neuronal courier services may do more than just deliver the goods

The messenger RNA, or mRNA, carries the genetic message from the nucleus into the cytoplasm where it is translated into a protein by ribosomes. How cells regulate where and when protein synthesis occur in very complex cells such as neurons remain a very active area of research. The EU-funded AXONENDO project is building on the discovery that mRNAs and ribosomes are present on moving vesicles called endosomes in the axons of neurons, hoping to tease out the mechanisms and a potential role in development and neuronal function. Endosomal trafficking in axons and dendrites is like a neuronal courier for fast and effective point-to-point delivery of goods. Now it could also play a key role in changing local protein expression in response to extracellular factors.

Call for proposal

ERC-2019-STG
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Host institution

OSPEDALE SAN RAFFAELE SRL
Address
Via Olgettina 60
20132 Milano
Italy
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 1 499 563

Beneficiaries (1)

OSPEDALE SAN RAFFAELE SRL
Italy
EU contribution
€ 1 499 563
Address
Via Olgettina 60
20132 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)