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Predicting comorbid cardiovascular disease in individuals with mental disorder by decoding disease mechanisms

Project description

Molecular mechanisms of comorbid cardiovascular disease in cases of severe mental disorder

Comorbid cardiovascular disease in cases of severe mental disorders is a major public health concern. Recent findings show that genetic variations that affect the brain and increase the risk of mental disorders also impact lifestyle and behaviour that increase risk of cardiovascular disease. The EU-funded project CoMorMent will investigate mechanisms underlying the higher incidence of cardiovascular disease in people with mental disorders. The study will take advantage of 1.8 million genotyped biobank samples from national registries with information about disease trajectories and comorbidity. It will uncover the underlying molecular mechanisms by identifying structural brain changes and body fat composition in combination with gene expression and functional studies. Ultimately, this project will help to create the basis for a new approach in clinical studies by providing precision medicine tools to deal with a major public health issue.

Call for proposal

H2020-SC1-2019-Two-Stage-RTD
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Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITETET I OSLO
Address
Problemveien 5-7
0313 Oslo
Norway
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 523 625

Participants (8)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 667 800
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
REGION HOVEDSTADEN
Denmark
EU contribution
€ 769 250
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
ISLENSK ERFDAGREINING EHF
Iceland
EU contribution
€ 818 750
Address
Sturlugotu 8
101 Reykjavik
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
TARTU ULIKOOL
Estonia
EU contribution
€ 553 125
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 532 756,25
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
AMRA MEDICAL AB
Sweden
EU contribution
€ 360 000
Address
Badhusgatan 5
582 22 Linkoping
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CORTECHS LABS INC
United States
EU contribution
€ 451 875
Address
4690 Executive Dr Suite 250
92121 San Diego
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HASKOLI ISLANDS
Iceland
EU contribution
€ 321 432,50
Address
Saemundargotu 2
101 Reykjavik
Activity type
Higher or Secondary Education Establishments