Human tissue organoid platform within the Human Cell Atlas initiative
The Human Cell Atlas project is a global scientific initiative with the goal to map and characterise all cells in the human body by types, numbers, locations, relationships and molecular structure. It is considered a fundamental future resource for scientists, enabling understanding of how healthy cells work and what happens in the case of a disease. The EU-funded HCA Organoid project will create a Human Organoid Atlas within the Human Cell Atlas initiative with the goal to deepen an ability to draw functional/causal/mechanistic conclusions relevant to human diseases. The project will establish single-cell transcriptomes, single-cell epigenomes and imaging data for several thousand organoids and matched primary tissue. Initially, focus will be on the colon and the brain with additional organs included as pilot studies. In general, this resource will enable characterisation of normal population variations and provide a baseline for disease studies.
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