Project description DEENESFRITPL Human tissue organoid platform within the Human Cell Atlas initiative The Human Cell Atlas project is a global scientific initiative with the goal to map and characterise all cells in the human body by types, numbers, locations, relationships and molecular structure. It is considered a fundamental future resource for scientists, enabling understanding of how healthy cells work and what happens in the case of a disease. The EU-funded HCA Organoid project will create a Human Organoid Atlas within the Human Cell Atlas initiative with the goal to deepen an ability to draw functional/causal/mechanistic conclusions relevant to human diseases. The project will establish single-cell transcriptomes, single-cell epigenomes and imaging data for several thousand organoids and matched primary tissue. Initially, focus will be on the colon and the brain with additional organs included as pilot studies. In general, this resource will enable characterisation of normal population variations and provide a baseline for disease studies. Show the project objective Hide the project objective Objective "Excellence: The Human Cell Atlas (HCA) is descriptive by definition, as it seeks to map all cells in the human body. Yet its goal of “understanding fundamental human biological processes and diagnosing, monitoring, and treating disease” (HCA Whitepaper) depends on our ability to draw functional/causal/mechanistic conclusions relevant to human diseases. Personalized organoid technology aptly fills this gap, as it makes human tissue amenable to functional studies and faithful disease modeling in vitro.This project will firmly establish a ""Human Organoid Atlas"" within the HCA. Initially focusing on two organs (colon and brain: 100 distinct organoid lines each). We will establish single-cell transcriptomes, single-cell epigenomes, and time-series imaging for several thousand organoids and matched primary tissue. This resource will primarily quantify normal population variation and provide a baseline for disease studies. Moreover, the project will include data generation and analysis of >20 colorectal cancer organoid lines with matching organoid lines derived from normal (healthy) material as well as the respective matching primary tissue. We will show the practical utility of the resource by proof-of-concept disease modeling for genetic epilepsy (brain) and large-scale characterization of disease-linked genetic variants (colon).Impact: 1. Deeply characterized organoid collection enables functional and disease-centric studies pursuing HCA insights. 2. Single-cell dataset provides reference of population variation under highly standardized conditions. 3. Linking single-cell profiling and organoids will boost HCA’s impact on human health.Implementation: The project connects the European founders of organoid research (Hans Clevers, Jürgen Knoblich) with expertise in large-scale epigenome/transcriptome profiling (Christoph Bock, Henk Stunnenberg), advanced imaging (Prisca Liberali, Anne Rios), bioinformatics and systems genetics (Oliver Stegle, Michael Boutros), data management (Laura Clarke/EBI), and strong SME contribution (Hubrecht Organoid Technology, Eurice). The project is fully committed to the HCA's values. It implements extensive data sharing and sustainability measures." Fields of science natural sciencesbiological sciencesgeneticsmedical and health sciencesbasic medicineneurologyepilepsymedical and health sciencesclinical medicineoncologycolorectal cancer Programme(s) H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and well-being H2020-EU.3.1.1. - Understanding health, wellbeing and disease Topic(s) SC1-BHC-31-2019 - Pilot actions to build the foundations of a human cell atlas Call for proposal H2020-SC1-BHC-2018-2020 See other projects for this call Sub call H2020-SC1-2019-Single-Stage-RTD Funding Scheme RIA - Research and Innovation action Coordinator CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH Net EU contribution € 1 111 597,50 Address Lazarettgasse 14 akh bt 25.3 1090 Wien Austria See on map Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 Participants (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all INSTITUT FUER MOLEKULARE BIOTECHNOLOGIE GMBH Austria Net EU contribution € 610 748,75 Address Dr bohrgasse 3 1030 Wien See on map Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 PRINSES MAXIMA CENTRUM VOOR KINDERONCOLOGIE BV Netherlands Net EU contribution € 923 125,00 Address Heidelberglaan 25 3584CS Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Other Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 STICHTING HUBRECHT ORGANOID TECHNOLOGY Netherlands Net EU contribution € 679 463,75 Address Yalelaan 62 3584 CM Utrecht See on map Region West-Nederland Utrecht Utrecht Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION Switzerland Net EU contribution € 634 475,00 Address Maulbeerstrasse 66 4058 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Germany Net EU contribution € 809 250,00 Address Im neuenheimer feld 280 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EUROPEAN MOLECULAR BIOLOGY LABORATORY Germany Net EU contribution € 69 777,50 Address Meyerhofstrasse 1 69117 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00 EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH Germany Net EU contribution € 160 250,00 Address Heinrich-hertz-allee 1 66386 St ingbert See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Saarland Saarland Saarpfalz-Kreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00