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3D Printed-Matrix Assisted Chemically Modified RNAs Bone Regenerative Therapy for Trauma and Osteoporotic Patients

Project description

Chemically modified RNAs and 3D printing in bone regenerative therapy

The ultimate goal of this EU-funded cmRNAbone project is to develop reliable bone regenerative technology to treat widespread bone traumatic injuries and osteoporosis-induced bone fragile fractures. Researchers aim to create a novel bone regenerative therapeutic approach using a combination of chemically modified RNAs and 3D printing technologies. Chemically modified RNAs of the growth factors targeting neurogenesis, vasculogenesis and osteogenesis will be synthesised together with vectors based on lipids and polysaccharide nanocapsules for the RNAs' delivery. Delivery of the vectors will be achieved with a 3D bioprinting process using hyaluronan-calcium phosphate biomaterial ink that can be loaded with vectors and able to be released later. This bio-ink will provide osteoinductivity and laminin-derived peptides for guiding sensory neurons and endothelial cells' ingrowth. The project aims to achieve preclinical proof of concept for selected drug candidates and prepare a first-in-human clinical trial.

Call for proposal

H2020-SC1-2019-Single-Stage-RTD
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Coordinator

AO-FORSCHUNGSINSTITUT DAVOS
Address
Clavadelerstrasse 8
7270 Davos Platz
Switzerland
Activity type
Research Organisations
EU contribution
€ 710 750

Participants (10)

UNIVERSITAT BASEL
Switzerland
EU contribution
€ 659 570
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments
ETHRIS GMBH
Germany
EU contribution
€ 490 526,25
Address
Semmelweisstr. 3
82152 Planegg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
EU contribution
€ 457 500
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACION CIDETEC
Spain
EU contribution
€ 443 500
Address
Paseo Miramon 196 Parque Tecnologico De Miramon
20014 San Sebastian
Activity type
Research Organisations
KUROS BIOSCIENCES BV
Netherlands
EU contribution
€ 435 138,75
Address
Professor Bronkhorstlaan 10 G 48
3723 MB Bilthoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OZ BIOSCIENCES SAS
France
EU contribution
€ 447 750
Address
Parc Scientifique Et Technologique De Luminy Case 922 Bat Ccimp
13288 Marseille
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUNDACION IDONIAL
Spain
EU contribution
€ 310 500
Address
Avenida Jardin Botanico 1345 Parque Cientifico Y Tecnologico Zona Intra
33203 Gijon
Activity type
Research Organisations
QBEX GMBH
Austria
EU contribution
€ 184 216,25
Address
St. Veiter Ring 1A
9020 Klagenfurt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 999 748,75
Address
Minderbroedersberg 4
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE BORDEAUX
France
EU contribution
€ 1 117 558,75
Address
Place Pey Berland 35
33000 Bordeaux
Activity type
Higher or Secondary Education Establishments