CORDIS
EU research results

CORDIS

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3D Printed-Matrix Assisted Chemically Modified RNAs Bone Regenerative Therapy for Trauma and Osteoporotic Patients

Project information

Grant agreement ID: 874790

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 6 256 758,75

  • EU contribution

    € 6 256 758,75

Coordinated by:

AO-FORSCHUNGSINSTITUT DAVOS

Switzerland

Project description

English EN

Chemically modified RNAs and 3D printing in bone regenerative therapy

The ultimate goal of this EU-funded cmRNAbone project is to develop reliable bone regenerative technology to treat widespread bone traumatic injuries and osteoporosis-induced bone fragile fractures. Researchers aim to create a novel bone regenerative therapeutic approach using a combination of chemically modified RNAs and 3D printing technologies. Chemically modified RNAs of the growth factors targeting neurogenesis, vasculogenesis and osteogenesis will be synthesised together with vectors based on lipids and polysaccharide nanocapsules for the RNAs' delivery. Delivery of the vectors will be achieved with a 3D bioprinting process using hyaluronan-calcium phosphate biomaterial ink that can be loaded with vectors and able to be released later. This bio-ink will provide osteoinductivity and laminin-derived peptides for guiding sensory neurons and endothelial cells' ingrowth. The project aims to achieve preclinical proof of concept for selected drug candidates and prepare a first-in-human clinical trial.

Coordinator

AO-FORSCHUNGSINSTITUT DAVOS

Address

Clavadelerstrasse 8
7270 Davos Platz

Switzerland

Activity type

Research Organisations

EU Contribution

€ 710 750

Participants (10)

UNIVERSITAT BASEL

Switzerland

EU Contribution

€ 659 570

ETHRIS GMBH

Germany

EU Contribution

€ 490 526,25

EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH

Germany

EU Contribution

€ 457 500

FUNDACION CIDETEC

Spain

EU Contribution

€ 443 500

KUROS BIOSCIENCES BV

Netherlands

EU Contribution

€ 435 138,75

OZ BIOSCIENCES SAS

France

EU Contribution

€ 447 750

FUNDACION IDONIAL

Spain

EU Contribution

€ 310 500

QBEX GMBH

Austria

EU Contribution

€ 184 216,25

UNIVERSITEIT MAASTRICHT

Netherlands

EU Contribution

€ 999 748,75

UNIVERSITE DE BORDEAUX

France

EU Contribution

€ 1 117 558,75

Project information

Grant agreement ID: 874790

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.3.

  • Overall budget:

    € 6 256 758,75

  • EU contribution

    € 6 256 758,75

Coordinated by:

AO-FORSCHUNGSINSTITUT DAVOS

Switzerland