Project description
Ribonucleoproteins remodelling in development and disease
A ribonucleoprotein (RNP) is a complex of ribonucleic acid and RNA-binding protein. These complexes play an integral part in important biological functions including DNA replication, gene expression regulation and RNA metabolism. Some mutations causing cancer or neurodegenerative diseases (such as amyotrophic lateral sclerosis) occur in RNA-binding proteins. These mutations are concentrated in the intrinsically disordered regions of the proteins which lack a well-defined 3D structure but play important roles in protein regulation, including RNP assembly and disassembly. The EU-funded RNPdynamics project will build a framework of experimental and computational methods to study the mechanisms of RNP remodelling, and to explore how such RNP dynamics contribute to cellular transitions in development and disease.
Fields of science
Programme(s)
Topic(s)
Funding Scheme
ERC-ADG - Advanced Grant
Host institution
1000 Ljubljana
Slovenia
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Beneficiaries (4)
1000 Ljubljana
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Participation ended
WC1E 6BT London
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
Participation ended
NW1 1AT London
WC2R 2LS London
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