CORDIS
EU research results

CORDIS

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Bacteria-mucin interactions – Shaping intestinal epithelial responses in health and disease

Project information

Grant agreement ID: 852452

Status

Ongoing project

  • Start date

    1 March 2020

  • End date

    28 February 2025

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 500 000

  • EU contribution

    € 1 500 000

Hosted by:

UNIVERSITEIT UTRECHT

Netherlands

Project description

English EN

Intestinal mucins and epithelial responses to bacteria

Human gut microbiota are the microorganisms of the digestive tract. Some represent a beneficial commensal bacteria but others could be pathobionts that cause inflammation. The intestinal mucus layer defines how specific microbiota members affect health and disease. The mucus layer has soluble mucins and epithelial transmembrane mucins that regulate host responses; the molecular mechanisms of these interactions are largely unknown. The EU-funded Bac2MUC project aims to identify molecular mechanisms via which distinct bacterial species regulate the functions of transmembrane mucins in the intestine. Earlier studies showed that mucin MUC1 is a key receptor for Salmonella invasion into epithelial cells, and MUC13 is a central regulator of epithelial barrier formation. The current project hypothesis is that bacteria-mucin interactions define epithelial responses by stimulating barrier formation, promoting inflammation or mediating bacterial invasion.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Host institution

UNIVERSITEIT UTRECHT

Address

Heidelberglaan 8
3584 Cs Utrecht

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 500 000

Beneficiaries (1)

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 1 500 000

Project information

Grant agreement ID: 852452

Status

Ongoing project

  • Start date

    1 March 2020

  • End date

    28 February 2025

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 500 000

  • EU contribution

    € 1 500 000

Hosted by:

UNIVERSITEIT UTRECHT

Netherlands