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Shaping the Mechano-Pharmacological properties of Microparticles and Extracellular Vesicles for the Treatment of Osteoarthritis

Project description

Polymeric microparticles for the treatment of osteoarthritis

Osteoarthritis is the most common form of arthritis when the protective cartilage that cushions the ends of bones wears down over time, affecting millions of people worldwide. The disorder most commonly affects joints in hands, knees, hips and spine, and often leads to joint replacement surgery. Presently, the condition is not curable and only a symptomatic treatment is available. The EU-funded MEPHOS project aims to develop a novel integrated strategy for osteoarthritis treatment based on the intra-articular deposition of polymeric microplates providing simultaneous long-term pharmacological therapy and mechanical support. Polymeric microplates will provide continuous release of pain management medication and combination of molecules and biologicals, to prevent tissue degeneration while inducing regeneration processes. The project is a collaborative effort of seven European and American academic institutions and industrial partners for fabrication and biological and preclinical evaluation.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells

Call for proposal

H2020-MSCA-RISE-2019
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
Address
Via Morego 30
16163 Genova
Italy
Activity type
Research Organisations
EU contribution
€ 312 800

Participants (3)

UNIVERSIDAD DE NAVARRA
Spain
EU contribution
€ 253 000
Address
Campus Universitario Edificio Central
31080 Pamplona
Activity type
Higher or Secondary Education Establishments
UNIVERSIDADE DO MINHO
Portugal
EU contribution
€ 225 400
Address
Largo Do Paco
4704 553 Braga
Activity type
Higher or Secondary Education Establishments
LIPOCURE LTD
Israel
EU contribution
€ 73 600
Address
Hadassah Ein Kerem Campus Building Jerusalem Biotechnology Park
91120 Jerusalem
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (4)

BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
United States
Address
Serra Mall 450
94305 2004 Stanford
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
United States
Address
"Airport Drive 104 Suite 2200 Cb #1350"
27599 Chapel Hill
Activity type
Higher or Secondary Education Establishments
VANDERBILT UNIVERSITY
United States
Address
West End Avenue 2201
37235 Nashville Tenessee
Activity type
Higher or Secondary Education Establishments
University of Arkansas
United States
Address
Ozark Hall, 1 University Of Arkansas 120
72701 Fayetteville
Activity type
Higher or Secondary Education Establishments