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A novel Stratified Medicine Algorithm to predict treatment responses to host-directed therapy in TB patients.

Project description

Stratified medicine algorithm to predict TB treatment response

Tuberculosis (TB) is an infectious disease affecting the lungs; left untreated, it is fatal for about half of those affected. Presently, one quarter of the world's population is infected with TB, with the European region showing the highest prevalence of drug-resistant TB. Host-directed therapy with anti-inflammatory effect has been proposed in addition to the current drug regimen, for a faster cure with less permanent lung damage. The EU-funded SMA-TB project will develop a personalised medicine approach, featuring stratification of patients and integration of pathogen and host factors. SMA-TB's main objectives include evaluation of aspirin's anti-inflammatory action in addition to therapy in drug-resistant cases, identification and clinical validation of host and pathogen biomarkers, and generation of an algorithm to stratify patients for predicting the course of the disease and its response to intervention.

Call for proposal

H2020-SC1-BHC-2018-2020

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Sub call

H2020-SC1-2019-Two-Stage-RTD

Coordinator

INSTITUT DE INVESTIGACIO EN CIENCIES DE LA SALUT GERMANS TRIAS I PUJOL
Net EU contribution
€ 1 679 624,86
Address
Ctra De Canyet S/n
08916 Badalona Barcelona
Spain

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Other funding
€ 1 679 624,86

Participants (8)

WITS HEALTH CONSORTIUM (PTY) LTD
South Africa
Net EU contribution
€ 1 107 324,14
Address
Princess Of Wales Terrace, Parktown, 31
2193 Johannesburg

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 1 107 324,14
NATIONAL CENTER FOR TUBERCULOSIS AND LUNG DISEASES JSC
Georgia
Net EU contribution
€ 599 141,25
Address
8 Adjara
0101 Tbilisi

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 599 141,25
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 656 910,00
Address
Rue Michel Ange 3
75794 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Other funding
€ 656 910,00
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 612 563,75
Address
Albinusdreef 2
2333 ZA Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Other funding
€ 612 563,75
OSLO UNIVERSITETSSYKEHUS HF
Norway
Net EU contribution
€ 840 125,00
Address
Kirkeveien 166 Tarnbygget
0450 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Higher or Secondary Education Establishments
Other funding
€ 840 125,00
ANAXOMICS BIOTECH SL
Spain
Net EU contribution
€ 428 250,00
Address
Calle Diputacio 237, P 1 Pta 1
08007 Barcelona

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 428 250,00
TES2A EUROPE CONSULTING AND BUSINESS DEVELOPMENT SL
Spain
Net EU contribution
€ 339 260,00
Address
Rbla Lluis Companys 18 (3,1)
08192 Sant Quirze Del Valles

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 339 260,00
LIONEX GMBH
Germany
Net EU contribution
€ 124 905,00
Address
Salzdahlumer Strasse 196
38126 Braunschweig

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Niedersachsen Braunschweig Braunschweig, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 124 905,00