Skip to main content

DECOMPENSATED CIRRHOSIS: IDENTIFICATION OF NEW COMBINATORIAL THERAPIES BASED ON SYSTEMS APPROACHES

Project description

Combinatorial therapy for decompensated cirrhosis

Cirrhosis mortality is mainly associated with cirrhosis decompensation (development of ascites, hepatic encephalopathy, gastrointestinal haemorrhage, and progression to acute-on-chronic liver failure (ACLF). Despite multiple treatments, mortality in patients with decompensation of cirrhosis remains high. The EU-funded DECISION project aims to understand the pathophysiology of decompensation of cirrhosis leading to ACLF or death, and to decrease patient mortality. The project will study the pathophysiology of decompensation of cirrhosis by integrating results of high-throughput multi-omic profiling with comprehensive clinical data from 2 200 fully characterised patients with available standardised biological samples. DECISION will help to identify novel combinatorial therapies to prevent high mortality for patients with decompensation of cirrhosis. Finally, researchers will optimise these therapies in new animal models and then test the best combination in high-risk patients in a Phase II clinical trial.

Field of science

  • /medical and health sciences/basic medicine/physiology/pathophysiology
  • /social sciences/sociology/demography/mortality

Call for proposal

H2020-SC1-2019-Two-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

EUROPEAN FOUNDATION FOR THE STUDY OF CHRONIC LIVER FAILURE (EF-CLIF)
Address
Travessera De Gracia 11, 7Th Floor
08021 Barcelona
Spain
Activity type
Research Organisations
EU contribution
€ 1 008 650

Participants (20)

FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
EU contribution
€ 396 722
Address
Carrer Rossello 149
08036 Barcelona
Activity type
Research Organisations
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 300 000
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 620 500
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN
Germany
EU contribution
€ 404 222
Address
Theodor W Adorno Platz 1
60323 Frankfurt Am Main
Activity type
Higher or Secondary Education Establishments
UNIVERSITAETSKLINIKUM AACHEN
Germany
EU contribution
€ 300 874
Address
Pauwelsstrasse 30
52074 Aachen
Activity type
Higher or Secondary Education Establishments
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
France
EU contribution
€ 345 000
Address
Rue Leblanc 25
75015 Paris 15
Activity type
Research Organisations
FUNDACION PUBLICA MIGUEL SERVET
Spain
EU contribution
€ 382 500
Address
Calle Irunlarrea 3 Centro Investigacion Biomedica Recinto Complejo Hospitalario De Navarra
31008 Pamplona
Activity type
Research Organisations
YH YOUHEALTH AB
Sweden
EU contribution
€ 260 000
Address
Fogdevreten 2 Karolinska Science
171 77 Stockholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
NORDIC BIOSCIENCE A/S
Denmark
EU contribution
€ 66 043
Address
Herlev Hovedgade 205-207
2730 Herlev
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 196 722
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
SERVICIO MADRILENO DE SALUD
Spain
EU contribution
€ 130 472
Address
Plaza Carlos Trias Bertran 7
28020 Madrid
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 130 879
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 42 500
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 130 472
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
INSTITUT CATALA DE LA SALUT
Spain
EU contribution
€ 130 472
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
UNIVERSITAT DE BARCELONA
Spain
EU contribution
€ 120 000
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Activity type
Higher or Secondary Education Establishments
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 445 472
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
EUROPEAN ASSOCIATION FOR THE STUDYOF THE LIVER
Switzerland
EU contribution
€ 50 000
Address
Lowenstrasse 1
8001 Zurich
Activity type
Other
EUROPEAN LIVER PATIENTS ASSOCIATION
Belgium
EU contribution
€ 50 000
Address
Rue De La Loi 235/27
1040 Bruxelles
Activity type
Other
Concentris Research Management GmbH
Germany
EU contribution
€ 488 500
Address
Ludwigstr. 4
D-82256 Fürstenfeldbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)