DECOMPENSATED CIRRHOSIS: IDENTIFICATION OF NEW COMBINATORIAL THERAPIES BASED ON SYSTEMS APPROACHES

Project description

Combinatorial therapy for decompensated cirrhosis

Cirrhosis mortality is mainly associated with cirrhosis decompensation (development of ascites, hepatic encephalopathy, gastrointestinal haemorrhage, and progression to acute-on-chronic liver failure (ACLF). Despite multiple treatments, mortality in patients with decompensation of cirrhosis remains high. The EU-funded DECISION project aims to understand the pathophysiology of decompensation of cirrhosis leading to ACLF or death, and to decrease patient mortality. The project will study the pathophysiology of decompensation of cirrhosis by integrating results of high-throughput multi-omic profiling with comprehensive clinical data from 2 200 fully characterised patients with available standardised biological samples. DECISION will help to identify novel combinatorial therapies to prevent high mortality for patients with decompensation of cirrhosis. Finally, researchers will optimise these therapies in new animal models and then test the best combination in high-risk patients in a Phase II clinical trial.

Fields of science

• medical and health sciences › basic medicine › physiology › pathophysiology
• social sciences › sociology › demography › mortality

Programme(s)

• H2020-EU.3.1.1. - Understanding health, wellbeing and disease

Topic(s)

• SC1-BHC-02-2019 - Systems approaches for the discovery of combinatorial therapies for complex disorders

Call for proposal

H2020-SC1-2019-Two-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

EUROPEAN FOUNDATION FOR THE STUDY OF CHRONIC LIVER FAILURE (EF-CLIF)

Address

Travessera De Gracia 11, 7Th Floor
08021 Barcelona
Spain

Activity type

Research Organisations

EU contribution

€ 1 008 650

Participants (20)

FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA

Spain

EU contribution

€ 396 722

Address

Carrer Rossello 149
08036 Barcelona

Activity type

Research Organisations

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU contribution

€ 300 000

Address

Dr Molewaterplein 40
3015 GD Rotterdam

Activity type

Higher or Secondary Education Establishments

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU contribution

€ 620 500

Address

Rue De Tolbiac 101
75654 Paris

Activity type

Research Organisations

JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN

Germany

EU contribution

€ 404 222

Address

Theodor W Adorno Platz 1
60323 Frankfurt Am Main

Activity type

Higher or Secondary Education Establishments

UNIVERSITAETSKLINIKUM AACHEN

Germany

EU contribution

€ 300 874

Address

Pauwelsstrasse 30
52074 Aachen

Activity type

Higher or Secondary Education Establishments

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU contribution

€ 345 000

Address

Rue Leblanc 25
75015 Paris 15

Activity type

Research Organisations

FUNDACION PUBLICA MIGUEL SERVET

Spain

EU contribution

€ 382 500

Address

Calle Irunlarrea 3 Centro Investigacion Biomedica Recinto Complejo Hospitalario De Navarra
31008 Pamplona

Activity type

Research Organisations

YH YOUHEALTH AB

Sweden

EU contribution

€ 260 000

Address

Fogdevreten 2 Karolinska Science
171 77 Stockholm

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

NORDIC BIOSCIENCE A/S

Denmark

EU contribution

€ 66 043

Address

Herlev Hovedgade 205-207
2730 Herlev

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA

Italy

EU contribution

€ 196 722

Address

Via Zamboni 33
40126 Bologna

Activity type

Higher or Secondary Education Establishments

SERVICIO MADRILENO DE SALUD

Spain

EU contribution

€ 130 472

Address

Plaza Carlos Trias Bertran 7
28020 Madrid

Activity type

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

UNIVERSITY COLLEGE LONDON

United Kingdom

EU contribution

€ 130 879

Address

Gower Street
WC1E 6BT London

Activity type

Higher or Secondary Education Establishments

UNIVERSITA DEGLI STUDI DI PADOVA

Italy

EU contribution

€ 42 500

Address

Via 8 Febbraio 2
35122 Padova

Activity type

Higher or Secondary Education Establishments

UNIVERSITA DEGLI STUDI DI TORINO

Italy

EU contribution

€ 130 472

Address

Via Giuseppe Verdi 8
10124 Torino

Activity type

Higher or Secondary Education Establishments

INSTITUT CATALA DE LA SALUT

Spain

EU contribution

€ 130 472

Address

Gran Via De Les Corts Catalanes 587
08007 Barcelona

Activity type

Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)

UNIVERSITAT DE BARCELONA

Spain

EU contribution

€ 120 000

Address

Gran Via De Les Corts Catalanes 585
08007 Barcelona

Activity type

Higher or Secondary Education Establishments

ASSISTANCE PUBLIQUE HOPITAUX DE PARIS

France

EU contribution

€ 445 472

Address

3 Avenue Victoria
75000 Paris

Activity type

Research Organisations

EUROPEAN ASSOCIATION FOR THE STUDYOF THE LIVER

Switzerland

EU contribution

€ 50 000

Address

Rue Daubin 7
1203 Geneve

Activity type

Other

EUROPEAN LIVER PATIENTS ASSOCIATION

Belgium

EU contribution

€ 50 000

Address

Rue De La Loi 235/27
1040 Bruxelles

Activity type

Other

Concentris Research Management GmbH

Germany

EU contribution

€ 488 500

Address

Ludwigstr. 4
D-82256 Fürstenfeldbruck

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)