CORDIS
EU research results

CORDIS

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Associative mechanisms linking a defective minipuberty to the appearance of mental and nonmental disorders: infantile NO replenishment as a new therapeutic possibility

Project information

Grant agreement ID: 847941

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2025

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 6 487 770

  • EU contribution

    € 6 487 770

Coordinated by:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

Project description

English EN

For better treatment of those born prematurely

Individuals born prematurely not only face increased risks as newborns but also suffer from multimorbidity in their later life. This is associated with adaptive changes of the hypothalamic-pituitary-gonadal axis during infancy, but the exact mechanisms underlying its malfunction and its consequences are largely unknown. The EU-funded miniNO project will conduct out pioneering research on the connection between alterations in minipuberty and infantile nitric oxide (NO) signaling in the brain, and comorbidities that appear later in life in prematurely born individuals. The project is based on previous clinical studies and solid data of the collaborating teams. It will create an extensive repertoire of clinical and genetic data, associating minipuberty and brain NO levels with mental and non-mental disorders, having as its main aim the search for explanations and treatments for the health burdens of millions of prematurely born people.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Rue De Tolbiac 101
75654 Paris

France

Activity type

Research Organisations

EU Contribution

€ 943 750

Participants (9)

BIOGAZELLE NV

Belgium

EU Contribution

€ 499 000

CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE

France

EU Contribution

€ 742 188,75

CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS

Switzerland

EU Contribution

€ 1 338 243,75

INSERM TRANSFERT SA

France

EU Contribution

€ 400 375

QUEEN MARY UNIVERSITY OF LONDON

United Kingdom

EU Contribution

€ 578 332,50

UNIVERSITE DE LILLE

France

EU Contribution

€ 539 605

UNIVERSITE DE GENEVE

Switzerland

EU Contribution

€ 347 750

EREVNITIKO PANEPISTIMIAKO INSTITUTOMELETIS KE ANTIMETOPISIS GENETIKONKE KAKOETHON NOSIMATON TIS PEDIKISILIKIAS

Greece

EU Contribution

€ 617 500

UNIVERSITAET zu LUEBECK

Germany

EU Contribution

€ 481 025

Project information

Grant agreement ID: 847941

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2025

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 6 487 770

  • EU contribution

    € 6 487 770

Coordinated by:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France