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THERVACB: A THERAPEUTIC VACCINE TO CURE HEPATITIS B

Project description

Novel therapeutic vaccine to cure hepatitis B

Spontaneous resolution of hepatitis b virus (HBV) infection is characterised by neutralising antibodies and HBV-specific T cell responses, elements which are lacking in chronic HBV infection. The EU-funded TherVacB project aims to overcome immune tolerance in chronic HBV infection and the virus’s resistance to cure. The interdisciplinary consortium will employ a heterologous prime-boost therapeutic vaccination scheme with proven efficacy in preclinical models of hepatitis B to target and activate B and T cell responses; thereby, TherVacB hopes to produce vaccine components and prepare a first-in-human application. To provide a clinical proof of concept of the therapeutic hepatitis B vaccine in patients with chronic hepatitis B, the consortium will establish a patient registry and perform a multicentre phase Ib/IIa clinical trial of the vaccine's safety and potency to induce immune control of chronic HBV infection.

Field of science

  • /natural sciences/biological sciences/microbiology/virology
  • /medical and health sciences/health sciences/infectious disease/DNA virus/hepatitis B
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug/vaccines
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins

Call for proposal

H2020-SC1-2019-Two-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Germany
Activity type
Research Organisations
EU contribution
€ 4 049 761,25

Participants (16)

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 1 394 787,50
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
NATIONAL INSTITUTE FOR MEDICAL RESEARCH
Tanzania
EU contribution
€ 489 287,50
Address
Sokoine Luthuli Drive Ocean Road
255 Dar Es Salaam
Activity type
Research Organisations
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Germany
EU contribution
€ 209 350
Address
Martinistrasse 52
20251 Hamburg
Activity type
Higher or Secondary Education Establishments
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
EU contribution
€ 153 750
Address
Carrer Rossello 149
08036 Barcelona
Activity type
Research Organisations
AZIENDA OSPEDALIERO-UNIVERSITARIA DI PARMA
Italy
EU contribution
€ 714 893,75
Address
Via Gramsci 14
43100 Parma
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 131 125
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
UNIVERSITY COLLEGE LONDON
United Kingdom
EU contribution
€ 536 023,75
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
CTC NORTH GMBH & CO KG
Germany
EU contribution
€ 1 113 125
Address
Martinistrasse 64
20251 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany
EU contribution
€ 146 500
Address
Inhoffenstrasse 7
38124 Braunschweig
Activity type
Research Organisations
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 675 380
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET LEIPZIG
Germany
EU contribution
€ 142 900
Address
Ritterstrasse 26
04109 Leipzig
Activity type
Higher or Secondary Education Establishments
BARTS AND THE LONDON NHS TRUST
United Kingdom
EU contribution
€ 104 500
Address
Prescot Street 9
E1 8PR London
Activity type
Research Organisations
ARTTIC

Participation ended

France
EU contribution
€ 35 323,14
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ROYAL FREE LONDON NHS FOUNDATION TRUST
United Kingdom
EU contribution
€ 100 000
Address
Pond Street Hampstead
NW3 2QG London
Activity type
Research Organisations
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 191 556,25
Address
Arcisstrasse 21
80333 Muenchen
Activity type
Higher or Secondary Education Establishments
ARTTIC INNOVATION GMBH
Germany
EU contribution
€ 237 423,11
Address
Oskar-von-miller-ring 29
80333 Munchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)