Skip to main content

Causative mechanisms & integrative models linking early-life-stress to psycho-cardio-metabolic multi-morbidity

Project description

The impact of early life stress in later life

Early life stress (ELS) is a major risk factor for depression and two of its main physical comorbidities, coronary heart disease and diabetes. Some research suggests that depression develops from a complex interaction between biological and psychological processes. The EU-funded EarlyCause project will identify the biological contributions from four key interconnected domains: epigenetics, inflammation, neuroendocrine system and microbiome. It will take into account the effects of factors such as sex/gender, socioeconomics, lifestyle and behaviour. The project will combine basic, pre-clinical and clinical research, including causal inference methods, animal models of potential and postnatal stress, cellular models in various tissues, integrative bioinformatics and machine learning methods. The findings will deepen our understanding of biomarkers and innovation outputs in relation to new integrated care pathways.

Call for proposal

H2020-SC1-BHC-2018-2020

See other projects for this call

Sub call

H2020-SC1-2019-Two-Stage-RTD

Coordinator

UNIVERSITAT DE BARCELONA
Net EU contribution
€ 680 937,50
Address
Gran Via De Les Corts Catalanes 585
08007 Barcelona
Spain

See on map

Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (13)

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Net EU contribution
€ 502 950,00
Address
Meyerhofstrasse 1
69117 Heidelberg

See on map

Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
Net EU contribution
€ 551 250,00
Address
Dr Molewaterplein 40
3015 GD Rotterdam

See on map

Region
West-Nederland Zuid-Holland Groot-Rijnmond
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAT ZURICH
Switzerland
Net EU contribution
€ 581 250,00
Address
Ramistrasse 71
8006 Zurich

See on map

Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
KING'S COLLEGE LONDON
United Kingdom
Net EU contribution
€ 465 685,00
Address
Strand
WC2R 2LS London

See on map

Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Net EU contribution
€ 398 427,50
Address
Calle Serrano 117
28006 Madrid

See on map

Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
Net EU contribution
€ 323 125,00
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden

See on map

Region
Grand Est Alsace Bas-Rhin
Activity type
Research Organisations
Non-EU contribution
€ 0,00
OULUN YLIOPISTO
Finland
Net EU contribution
€ 508 000,00
Address
Pentti Kaiteran Katu 1
90014 Oulu

See on map

Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
PROVINCIA LOMBARDO VENETA - ORDINEOSPEDALIERO DI SAN GIOVANNI DI DIO- FATEBENEFRATELLI
Italy
Net EU contribution
€ 320 950,00
Address
Via Pilastroni 4
25125 Brescia

See on map

Region
Nord-Ovest Lombardia Brescia
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITY OF BATH
United Kingdom
Net EU contribution
€ 418 663,75
Address
Claverton Down
BA2 7AY Bath

See on map

Region
South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bath and North East Somerset, North Somerset and South Gloucestershire
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
STICHTING VUMC
Netherlands
Net EU contribution
€ 419 080,00
Address
De Boelelaan 1117
1081 HV Amsterdam

See on map

Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Non-EU contribution
€ 0,00
EMPIRICA GESELLSCHAFT FUR KOMMUNIKATIONS UND TECHNOLOGIEFORSCHUNG MBH
Germany
Net EU contribution
€ 430 625,00
Address
Oxfordstrasse 2
53111 Bonn

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
COMBINOSTICS OY
Finland
Net EU contribution
€ 325 500,00
Address
Hatanpään Valtatie 24
33100 Tampere

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Manner-Suomi Länsi-Suomi Pirkanmaa
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSIDAD POMPEU FABRA
Spain
Net EU contribution
€ 70 937,50
Address
Placa De La Merce, 10-12
08002 Barcelona

See on map

Region
Este Cataluña Barcelona
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00