CORDIS
EU research results

CORDIS

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Ribitol-phosphate: chemical tools to probe the biology of a unique mammalian carbohydrate

Project information

Grant agreement ID: 851448

Status

Ongoing project

  • Start date

    1 February 2020

  • End date

    31 January 2025

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 494 411

  • EU contribution

    € 1 494 411

Hosted by:

UNIVERSITY OF YORK

United Kingdom

Project description

English EN

Study of faulty glycan could aid treatment of devastating muscle diseases

Proteins are the workhorses of cells, the building block of molecules for receptors, immunoglobulins, hormones and more. During or after translation, the majority of proteins are 'decorated' with carbohydrates in a process called glycosylation, a highly regulated process that affects their 3D structure, function, and stability. When it goes awry, malfunctioning proteins can play a role in disease processes. The EU-funded RibiTool project is investigating a unique cell-surface glycan whose faulty assembly results in the forms of congenital muscular dystrophy (muscle diseases characterised by progressive muscle degeneration) called α-dystroglycanopathies. Tools developed within the project will enable study of the assembly, structure and function of the glycan that could open the door to therapies for these devastating diseases.

Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Host institution

UNIVERSITY OF YORK

Address

Heslington
Yo10 5dd York North Yorkshire

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 494 411

Beneficiaries (1)

UNIVERSITY OF YORK

United Kingdom

EU Contribution

€ 1 494 411

Project information

Grant agreement ID: 851448

Status

Ongoing project

  • Start date

    1 February 2020

  • End date

    31 January 2025

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 494 411

  • EU contribution

    € 1 494 411

Hosted by:

UNIVERSITY OF YORK

United Kingdom