Project description
Simpler and more effective bone regeneration therapy
Mesenchymal stem cells (MSCs) are multipotent stem cells capable of differentiating into multiple cell types including osteoblasts and osteocytes. Over the past couple of decades, MSC therapy has been used clinically to promote bone healing and regeneration. However, its efficacy depends on numerous factors. Moreover, BMSCs are harvested from donors' bone marrow, adding discomfort and complexity to the process. The EU-funded EVEREST project is seeking to eliminate the need for the cells themselves by getting straight to the source of their activity. MSCs secrete extracellular vesicles (EVs) loaded with bioactive cargo. Scientists are focusing on elucidating which EV component is critical to bone regeneration and harnessing it for cell-free targeted EV therapy.
Fields of science
- natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acids
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- natural sciencesbiological sciencesbiochemistrybiomoleculeslipids
- medical and health sciencesmedical biotechnologycells technologiesstem cells
- engineering and technologynanotechnologynano-materials
Topic(s)
Call for proposal
ERC-2019-STG
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Funding Scheme
ERC-STG - Starting Grant
Host institution
H91 Galway
Ireland
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Beneficiaries (2)
H91 Galway
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Participation ended
75654 Paris
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