Skip to main content

Extracellular Vesicles for Bone Regeneration – alternatives to Stem-cell Therapy

Project description

Simpler and more effective bone regeneration therapy

Mesenchymal stem cells (MSCs) are multipotent stem cells capable of differentiating into multiple cell types including osteoblasts and osteocytes. Over the past couple of decades, MSC therapy has been used clinically to promote bone healing and regeneration. However, its efficacy depends on numerous factors. Moreover, BMSCs are harvested from donors' bone marrow, adding discomfort and complexity to the process. The EU-funded EVEREST project is seeking to eliminate the need for the cells themselves by getting straight to the source of their activity. MSCs secrete extracellular vesicles (EVs) loaded with bioactive cargo. Scientists are focusing on elucidating which EV component is critical to bone regeneration and harnessing it for cell-free targeted EV therapy.

Call for proposal

ERC-2019-STG
See other projects for this call

Host institution

NATIONAL UNIVERSITY OF IRELAND GALWAY
Address
University Road
H91 Galway
Ireland

See on map

Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 499 925

Beneficiaries (2)

NATIONAL UNIVERSITY OF IRELAND GALWAY
Ireland
EU contribution
€ 1 499 925
Address
University Road
H91 Galway

See on map

Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Participation ended

France
EU contribution
€ 0
Address
Rue De Tolbiac 101
75654 Paris

See on map

Activity type
Research Organisations