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Structure and Cellular Dynamics of the Sarcomere

Objective

Muscles are specialized tissues that power voluntary, fast and coordinated movements, a hallmark of animal life. The force-generating and load-bearing devices of muscles are called sarcomeres, highly structured ensembles of many proteins. While many sub-components are structurally and functionally characterised, muscle is more than the sum of these parts: its function is highly cooperative and its structure dynamic over time and space. The high-resolution structure of sarcomeres is unknown, yet a precise molecular understanding of how the entire sarcomere machine forms and functions is required to understand its role in health, disease and ageing. This consortium will deploy an unparalleled complementary knowledge and technology base to address these fundamental and translational questions. We will solve the structure of the sarcomere at near-atomic resolution, uMuscles are specialized tissues that power voluntary, fast and coordinated movements, a hallmark of animal life. The force-generating and load-bearing devices of muscles are called sarcomeres, highly structured ensembles of many proteins. While many sub-components are structurally and functionally characterised, muscle is more than the sum of these parts: its function is highly cooperative and its structure dynamic over time and space. The high-resolution structure of sarcomeres is unknown, yet a precise molecular understanding of how the entire sarcomere machine forms and functions is required to understand its role in health, disease and ageing. This consortium will deploy an unparalleled complementary knowledge and technology base to address these fundamental and translational questions. We will solve the structure of the sarcomere at near-atomic resolution, unravel the fundamentals of its force-driven assembly and turnover in health and ageing, and develop the foundations for future basic and translational research including the design and development of new agents to mitigate muscle disease and ageing.

Call for proposal

ERC-2019-SyG
See other projects for this call

Funding Scheme

ERC-SyG - Synergy grant

Host institution

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Address
Hofgartenstrasse 8
80539 Muenchen
Germany
Activity type
Research Organisations
EU contribution
€ 5 000 000

Beneficiaries (3)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 5 000 000
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 2 499 190
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 3 437 250
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations