CORDIS
EU research results

CORDIS

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Fast optoacoustic mesoscopy, using the skin as a window for therapeutic monitoring of local and systemic disease.

Project information

Grant agreement ID: 871763

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2024

Funded under:

H2020-EU.2.1.1.

  • Overall budget:

    € 5 111 203,75

  • EU contribution

    € 4 292 170

Coordinated by:

TECHNISCHE UNIVERSITAET MUENCHEN

Germany

Objective

Optoacoustic (photoacoustic) imaging dramatically improves upon conventional bio-optic barriers and enables three-dimensional, high-resolution optical imaging deep inside tissues (several mm to cm). Clinical optoacoustic macroscopy has been supported by two ERC Advanced Awards (2008, 2016; Prof. Ntziachristos). In parallel, under the ICT program INNODERM, we developed mesoscopic optoacoustic imaging for dermatology diagnostics. Termed raster-scan optoacoustic mesoscopy (RSOM), the method can image previously invisible ❶ pathophysiological/oxygenation and ❷ morphological features of the skin at depths of 1-5mm. RSOM has already shown clinical diagnostic value in dermatology and, fuelled by INNODERM, has been commercialised and globally placed by iThera Medical.
WINTHER builds on this success. While INNODERM focused on diagnostic dermatology, it has become apparent that RSOM can also assess progression and therapy not only in skin but also in cardiovascular diseases and diabetes. However, to achieve this, RSOM should be able to assess endothelial function, ability that it is not yet available. WINTHER will build next-generation fast RSOM (F-RSOM), operating up to two orders of magnitude faster than state-of-the-art RSOM, enabling it to assess not only ❶,❷ above but also ❸ endothelial function. Using the skin as a window for disease assessment and aided by a modern computation framework, based on deterministic and artificial intelligence algorithms, F-RSOM aims to improve the clinical accuracy of RSOM and shift the paradigm in therapeutic monitoring of cardio-metabolic diseases and inflammatory skin conditions, strengthening Europe's leadership in photonics and in personalized medicine.
The project is driven iThera Medical with a strong history of commercializing optoacoustics for clinical applications, by leading physicians (TUM, HUNIMED), and by RSOM, RSOM components and data analysis experts (TUM, iThera, Rayfos, Sonaxis).
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Coordinator

TECHNISCHE UNIVERSITAET MUENCHEN

Address

Arcisstrasse 21
80333 Muenchen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 521 091,25

Participants (4)

SONAXIS SA

France

EU Contribution

€ 470 741,25

RAYFOS LTD

United Kingdom

EU Contribution

€ 493 500

ITHERA MEDICAL GMBH

Germany

EU Contribution

€ 946 837,50

HUMANITAS UNIVERSITY

Italy

EU Contribution

€ 860 000

Project information

Grant agreement ID: 871763

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2024

Funded under:

H2020-EU.2.1.1.

  • Overall budget:

    € 5 111 203,75

  • EU contribution

    € 4 292 170

Coordinated by:

TECHNISCHE UNIVERSITAET MUENCHEN

Germany