CORDIS
EU research results

CORDIS

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Dynamic longitudinal exposome trajectories in cardiovascular and metabolic non-communicable diseases

Project information

Grant agreement ID: 874739

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2024

Funded under:

H2020-EU.3.1.2.

  • Overall budget:

    € 11 997 448,75

  • EU contribution

    € 11 997 448,75

Coordinated by:

OULUN YLIOPISTO

Finland

Objective

Environmental factors, including air and noise pollution, and the built environment, are typically associated with cardiovascular and metabolic non-communicable diseases (NCDs), e.g. obesity, type 2 diabetes, heart diseases and atherosclerosis. The extent to which these exposures may cause their attributed health effects (via molecular mediation) directly or indirectly as a result of associations to an individual’s psychosocial context is largely unknown. NCDs arise from a lifelong process influencing anthropometric, glycaemic, cardiac and lipid-related health trajectories. Risks may start as early as during the fetal period and are modified during sensitive periods in childhood, adolescence and adulthood. Despite this, research has not focused enough on the life-course characterisation of the exposome and the application of this to health and disease. In 5 years, LONGITOOLS, a partnership of 15 academic groups and 3 small companies will harness a catalogue of birth cohorts, longitudinal data, registers and biobanks. We will characterise coincident longitudinal trajectories of exposure and cardiometabolic health combining the study of longitudinal effects and internal responses. The latter will include measures of DNA methylation, RNA expression and read outs of metabolic pathways. LONGITOOLS will implement this longitudinal approach in 11 work packages designed to generate a catalogue of FAIR data and a novel analytical toolbox. Evidence-based life-course causal models will estimate how clinical and policy interventions may sustainably affect the health and economic burden of NCDs. A key objective will be to generate evidence-based predictions which can ultimately translate into innovative healthcare applications (apps) and policy options. LONGITOOLS will also allow researchers and policy makers to generate new knowledge - identifying the likely causal (direct and indirect) mechanisms through which exposures to man-made environmental factors affect the risk of NCDs. LONGITOOLS is one of the nine projects composing the European Human Exposome Network.

Coordinator

OULUN YLIOPISTO

Address

Pentti Kaiteran Katu 1
90014 Oulu

Finland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 171 875

Participants (17)

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 896 160

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 796 910

BETA TECHNOLOGY LTD

United Kingdom

EU Contribution

€ 647 870

ITA-SUOMEN YLIOPISTO

Finland

EU Contribution

€ 987 595

CHALMERS TEKNISKA HOEGSKOLA AB

Sweden

EU Contribution

€ 427 941,25

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands

EU Contribution

€ 600 625

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France

EU Contribution

€ 451 375

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 729 781,25

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 524 257,50

UNIVERSITY OF SURREY

United Kingdom

EU Contribution

€ 682 347,50

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

EU Contribution

€ 552 321,25

UNIVERSITETET I OSLO

Norway

EU Contribution

€ 500 942,50

UNIVERSITY OF BRISTOL

United Kingdom

EU Contribution

€ 808 992,50

UNIVERSITAT DE BARCELONA

Spain

EU Contribution

€ 716 250

AB.ACUS SRL

Italy

EU Contribution

€ 574 125

CYNEXO SRL

Italy

EU Contribution

€ 372 955

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA

Italy

EU Contribution

€ 555 125

Project information

Grant agreement ID: 874739

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2024

Funded under:

H2020-EU.3.1.2.

  • Overall budget:

    € 11 997 448,75

  • EU contribution

    € 11 997 448,75

Coordinated by:

OULUN YLIOPISTO

Finland