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New Generation Cell Therapy: Bioartificial Pancreas to Cure Type 1 Diabetes

Project description

Pancreatic organoid could end insulin injections for type 1 diabetes

The food we eat supplies our bodies with critical energy throughout the day. Digested food enters the bloodstream as glucose, to be absorbed by other cells with the help of insulin, a hormone secreted by the pancreas. In diabetes, circulating blood glucose levels are too high. Type 2 diabetes, attributable to diminished capacity to make or use insulin, is treated with lifestyle changes and oral medication. In type 1 diabetes, however, the pancreas makes no insulin at all, and daily insulin shots are required. The EU-funded VANGUARD project is developing an implantable artificial pancreas, an insulin-producing organoid of biological origin. Just the right combination of cell types and hydrogel will encourage growth and vascularisation of functional tissue, and ensure biocompatibility, safety and efficacy. The team plans to make the treatment accessible to all patients.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug
  • /medical and health sciences/clinical medicine/transplantation
  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /medical and health sciences/basic medicine/immunology

Call for proposal

H2020-SC1-2019-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITE DE GENEVE
Address
Rue Du General Dufour 24
1211 Geneve
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 995 946,25

Participants (8)

UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO
Italy
EU contribution
€ 936 875
Address
Duomo 6
13100 Vercelli
Activity type
Higher or Secondary Education Establishments
UNIVERSITE LYON 1 CLAUDE BERNARD
France
EU contribution
€ 523 812,50
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
Activity type
Higher or Secondary Education Establishments
OSPEDALE SAN RAFFAELE SRL
Italy
EU contribution
€ 1 049 500
Address
Via Olgettina 60
20132 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
EU contribution
€ 804 375
Address
Geschwister Scholl Platz 1
80539 Muenchen
Activity type
Higher or Secondary Education Establishments
KUGELMEIERS AG
Switzerland
EU contribution
€ 701 250
Address
Bahnhofstrasse 40
8703 Erlenbach
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EUROPEAN SOCIETY FOR ORGAN TRANSPLANTATION
Netherlands
EU contribution
€ 55 000
Address
Westerdoksdijk 423
1013 BX Amsterdam
Activity type
Other
ACCELOPMENT AG
Switzerland
EU contribution
€ 384 750
Address
Seefeldstrasse 198
8008 Zuerich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Netherlands
EU contribution
€ 393 116,25
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Activity type
Higher or Secondary Education Establishments