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Human Exposomic Determinants of Immune Mediated Diseases

Project information

Grant agreement ID: 874864

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2024

Funded under:

H2020-EU.3.1.2.

  • Overall budget:

    € 11 992 338,75

  • EU contribution

    € 11 992 338,75

Coordinated by:

TAMPEREEN KORKEAKOULUSAATIO SR

Finland

Objective

Immune-mediated diseases (IMDs) are increasing rapidly in the developed countries constituting a huge medical, economic and societal challenge. The reasons to this epidemic are not known, but exposome needs to play an important role since genetic factors cannot explain such a rapid change. In the HEDIMED project altogether 20 academic and industrial partners will join their multidisciplinary and supplementary forces to identify exposomic determinants which are driving this epidemic. The project is based on a combination of data and biological samples from large clinical cohorts constituting the largest clinical resource in this field including 350.000 pregnant women, 28.000 children prospectively followed from birth and 6.600 children from cross-sectional studies. HEDIMED focuses on common chronic IMDs that cause a significant disease burden, including type 1 diabetes, celiac disease, allergies and asthma. Exposomic disease determinants and the underlying biological pathways will be identified by exploratory approach using advanced omics and multiplex technologies combined with cutting–edge datamining technologies. Particular emphasis is paid on early fetal and childhood exposome since the disease process is known to start early. Inclusion of several IMDs makes it possible to identify determinants that are common for many IMDs facilitating the development of widely operating treatments. HEDIMED includes also data and samples from clinical trials that have used exposomice interventions and cell and organ culture models to help the identification of causal associations. HEDIMED will generate an open-access toolbox that offers various kind of data, new technologies, interactions forums, latest information and functional tools for several stakeholders to facilitate the efforts to find ways to control the IMD epidemic. HEDIMED will generate several innovations which can become exploited widely in diagnostic, therapeutic, preventive and health-economical applications. HEDIMED will work together with the other projects (EXPANSE, HEAP, ATHLETE, EQUAL-LIFE, LONGITOOLS, EPHOR, REMEDIA and EXIMIOUS) funded within the Human Exposome programme call H2020 SC1-BHC-2018-2020, in order to achieve collaboration and synergy
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Coordinator

TAMPEREEN KORKEAKOULUSAATIO SR

Address

Kalevantie 4
33100 Tampere

Finland

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 562 782,50

Participants (21)

LUNDS UNIVERSITET

Sweden

EU Contribution

€ 646 512,50

HELSINGIN YLIOPISTO

Finland

EU Contribution

€ 522 242,50

FOLKEHELSEINSTITUTTET

Norway

EU Contribution

€ 644 373,75

TURUN YLIOPISTO

Finland

EU Contribution

€ 1 160 371,25

OULUN YLIOPISTO

Finland

EU Contribution

€ 287 096,25

SIHTASUTUS TARTU ULIKOOLI KLIINIKUM

Estonia

EU Contribution

€ 467 550

UNIVERSITA DEGLI STUDI DI SIENA

Italy

EU Contribution

€ 457 602,50

TERVEYDEN JA HYVINVOINNIN LAITOS

Finland

EU Contribution

€ 586 925

UNIVERZITA KARLOVA

Czechia

EU Contribution

€ 816 037,50

CESKA ZEMEDELSKA UNIVERZITA V PRAZE

Czechia

EU Contribution

€ 298 436,25

Teknologian tutkimuskeskus VTT Oy

Finland

EU Contribution

€ 954 253,75

TARTU ULIKOOL

Estonia

EU Contribution

€ 417 811,25

CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT

Switzerland

EU Contribution

€ 355 930

TECHNISCHE UNIVERSITAET GRAZ

Austria

EU Contribution

€ 470 233,75

BAYLOR COLLEGE OF MEDICINE

United States

EU Contribution

€ 596 872,50

EMPIRICA GESELLSCHAFT FUR KOMMUNIKATIONS UND TECHNOLOGIEFORSCHUNG MBH

Germany

EU Contribution

€ 249 572,50

SATELLIO OY

Finland

EU Contribution

€ 219 351,25

GNOMON Informatics SA

Greece

EU Contribution

€ 279 858,75

DEN SELVEJENDE INSTITUTION DANSK BORNEASTMA CENTER

Denmark

EU Contribution

€ 397 915

PIRKANMAA HOSPITAL DISTRICT

Finland

EU Contribution

€ 414 205

LUONNONVARAKESKUS

Finland

EU Contribution

€ 186 405

Project information

Grant agreement ID: 874864

Status

Ongoing project

  • Start date

    1 January 2020

  • End date

    31 December 2024

Funded under:

H2020-EU.3.1.2.

  • Overall budget:

    € 11 992 338,75

  • EU contribution

    € 11 992 338,75

Coordinated by:

TAMPEREEN KORKEAKOULUSAATIO SR

Finland