Project description
Determining the recipe for success in DNA damage control
The integrity of our genetic material must be maintained to ensure proper functioning of our cells and tissues, our viability and procreation, and the transfer of intact and functional genetic material to the next generation. Our trillions of cells receive thousands of DNA lesions daily, whether through physiological processes or insults and toxins. To combat this threat, cells have evolved the DNA-damage response (DDR), a complex collective set of mechanisms that detect DNA lesions, signal their presence and promote their repair. While DNA repair pathways have recently been exploited to treat diseases, the mechanisms are not fully understood. The EU-funded DDREAMM project is investigating DDR pathways to identify factors for sensitivity to DNA-damaging agents, DDR deficiency, and resistance to DDR-targeting treatments. Outcomes should lead to tools allowing precise control of DNA repair, and to therapies for numerous diseases.
Fields of science
Topic(s)
Call for proposal
ERC-2019-SyG
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Funding Scheme
ERC-SyG - Synergy grantHost institution
8092 Zuerich
Switzerland
Beneficiaries (4)
8092 Zuerich
Participation ended
1090 Wien
CB2 1TN Cambridge
1090 Wien