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Dna Damage REsponse: Actionabilities, Maps and Mechanisms

Project description

Determining the recipe for success in DNA damage control

The integrity of our genetic material must be maintained to ensure proper functioning of our cells and tissues, our viability and procreation, and the transfer of intact and functional genetic material to the next generation. Our trillions of cells receive thousands of DNA lesions daily, whether through physiological processes or insults and toxins. To combat this threat, cells have evolved the DNA-damage response (DDR), a complex collective set of mechanisms that detect DNA lesions, signal their presence and promote their repair. While DNA repair pathways have recently been exploited to treat diseases, the mechanisms are not fully understood. The EU-funded DDREAMM project is investigating DDR pathways to identify factors for sensitivity to DNA-damaging agents, DDR deficiency, and resistance to DDR-targeting treatments. Outcomes should lead to tools allowing precise control of DNA repair, and to therapies for numerous diseases.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/genome
  • /natural sciences/biological sciences/genetics and heredity/dna
  • /natural sciences/chemical sciences/analytical chemistry/mass spectrometry
  • /medical and health sciences/clinical medicine/cancer

Call for proposal

ERC-2019-SyG
See other projects for this call

Funding Scheme

ERC-SyG - Synergy grant

Host institution

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Address
Raemistrasse 101
8092 Zuerich
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 3 428 750

Beneficiaries (4)

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 3 428 750
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
CEMM - FORSCHUNGSZENTRUM FUER MOLEKULARE MEDIZIN GMBH

Participation ended

Austria
EU contribution
€ 0
Address
Lazarettgasse 14 Akh Bt 25.3
1090 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 2 483 215
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 2 954 000
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments