Untangling interactions of the smallest, most numerous organisms on Earth
Bacteriophages (also called phages, bacteria-infecting viruses) are the most numerous, diverse, and uninvestigated group of organisms on Earth. Recent computational and technological advances have identified an unprecedented diversity of phages in different environments such as the human gut and the ocean's depths. Meanwhile, understanding the functions of all these phages is lagging far behind. The evolutionary interactions between phages and their hosts have led to an incredible variety of molecular mechanisms, several of which led to groundbreaking biotechnological applications. Given the critical role of phages in medicine and biotechnology, including as an alternative to antibiotics to combat specific bacterial pests and pathogens, understanding what enables a phage to infect a host is critical. The EU-funded DiversiPHI project is developing and applying new computational and experimental methods to better understand the evolution of phage-host interactions.
Fields of science
Funding SchemeERC-COG - Consolidator Grant
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3584 CS Utrecht
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