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Predicting the evolution of complex phage-host interactions

Project description

Untangling interactions of the smallest, most numerous organisms on Earth

Bacteriophages (also called phages, bacteria-infecting viruses) are the most numerous, diverse, and uninvestigated group of organisms on Earth. Recent computational and technological advances have identified an unprecedented diversity of phages in different environments such as the human gut and the ocean's depths. Meanwhile, understanding the functions of all these phages is lagging far behind. The evolutionary interactions between phages and their hosts have led to an incredible variety of molecular mechanisms, several of which led to groundbreaking biotechnological applications. Given the critical role of phages in medicine and biotechnology, including as an alternative to antibiotics to combat specific bacterial pests and pathogens, understanding what enables a phage to infect a host is critical. The EU-funded DiversiPHI project is developing and applying new computational and experimental methods to better understand the evolution of phage-host interactions.

Host institution

FRIEDRICH-SCHILLER-UNIVERSITAT JENA
Net EU contribution
€ 1 535 625,00
Address
Furstengraben 1
07743 Jena
Germany

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Region
Thüringen Thüringen Jena, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 535 625,00

Beneficiaries (2)

FRIEDRICH-SCHILLER-UNIVERSITAT JENA
Germany
Net EU contribution
€ 1 535 625,00
Address
Furstengraben 1
07743 Jena

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Region
Thüringen Thüringen Jena, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 1 535 625,00
UNIVERSITEIT UTRECHT
Netherlands
Net EU contribution
€ 464 375,00
Address
Heidelberglaan 8
3584 CS Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Other funding
€ 464 375,00