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(Photo-)Control of Persisters: Targeting the Magic Spot

Project description

Persistence is not always a desirable trait

Persistence in the face of adversity is often rewarded with victory over obstacles; unfortunately for us, this is also true for many bacteria under attack by antibiotics. While much attention is given to antimicrobial resistance, so-called persistence is an equally challenging public health problem. Bacterial persisters that can revive after antibiotic treatment stops have an important pathway mediating the ‘stringent response’ that is not seen in mammals. Despite significant research into this ubiquitous pathway in bacteria, enhanced knowledge has so far not been translated into biochemical approaches to modulate it and combat the inefficacy of some antibiotics. The EU-funded PP-MAGIC project is investigating the molecular mechanisms of the stringent response with a goal of inhibiting it with light. Insight could lead to novel therapies against this subgroup of bacteria, minimising the occurrence of chronic bacterial infections.

Host institution

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Net EU contribution
€ 2 000 000,00
Address
Fahnenbergplatz
79098 Freiburg
Germany

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Beneficiaries (1)

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
Net EU contribution
€ 2 000 000,00
Address
Fahnenbergplatz
79098 Freiburg

See on map

SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00