Persistence is not always a desirable trait
Persistence in the face of adversity is often rewarded with victory over obstacles; unfortunately for us, this is also true for many bacteria under attack by antibiotics. While much attention is given to antimicrobial resistance, so-called persistence is an equally challenging public health problem. Bacterial persisters that can revive after antibiotic treatment stops have an important pathway mediating the ‘stringent response’ that is not seen in mammals. Despite significant research into this ubiquitous pathway in bacteria, enhanced knowledge has so far not been translated into biochemical approaches to modulate it and combat the inefficacy of some antibiotics. The EU-funded PP-MAGIC project is investigating the molecular mechanisms of the stringent response with a goal of inhibiting it with light. Insight could lead to novel therapies against this subgroup of bacteria, minimising the occurrence of chronic bacterial infections.
Fields of science
- natural sciencesbiological sciencesmicrobiologybacteriology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- natural sciencesbiological sciencesgeneticsnucleotides
- natural sciencesbiological scienceszoologymammalogy
Funding SchemeERC-COG - Consolidator Grant
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.