CORDIS
EU research results

CORDIS

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Quantifying minute forces: How mechanoregulation determines the behavior of pathogenic bacteria

Project information

Grant agreement ID: 852585

Status

Grant agreement signed

  • Start date

    1 August 2020

  • End date

    31 July 2025

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 498 864

  • EU contribution

    € 1 498 864

Hosted by:

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

Project description

English EN

Nanoscopic force measurements reveal how bacteria ‘flex their muscles’

In addition to electrical and chemical signalling, organisms and cells utilise mechanical inputs and outputs to perform their essential functions. In response to chemo-mechanical cues, bacteria generate traction forces that are critical to their ability to colonise surfaces, create biofilms and invade host cells. However, the pathways transducing input to outputs and even the actual inputs and outputs themselves are poorly understood, in large part due to the difficulty of measuring these minute forces in freely moving bacteria. The EU-funded BacForce project is developing pioneering methods to observe these forces. Experimental techniques combined with computer simulations will enable scientists to manipulate and characterise bacterial traction-force generation with important insights for biofilm formation and broad-sweeping application to nanoscopic force generation in cells.

Host institution

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Address

Geschwister Scholl Platz 1
80539 Muenchen

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 498 864

Beneficiaries (1)

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 1 498 864

Project information

Grant agreement ID: 852585

Status

Grant agreement signed

  • Start date

    1 August 2020

  • End date

    31 July 2025

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 498 864

  • EU contribution

    € 1 498 864

Hosted by:

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany