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Mechanisms of dynamic localization of the bacterial Type 6 secretion system assembly

Project description

Bacterial Type 6 secretion system

The Type 6 secretion system (T6SS) allows bacteria to deliver toxins into both eukaryotic and bacterial target cells causing disease or killing competitors. T6SS has several main parts, including a membrane complex, baseplate and long spring-like sheath wrapped around an inner tube. Sheath contraction generates energy to push the tube with toxins through the baseplate and membrane complex out of the cell. Direct contact with the target membrane and precise positioning of T6SS is required for efficient protein translocation. The EU-funded project AimingT6SS will investigate principles of spatial and temporal control of localisation of protein complexes to better understand how it allows bacteria to respond to external cues and interact with the environment. Researchers will study how bacteria sense attacks from other bacteria to dynamically reposition their T6SS. Genetic and biochemical approaches will characterise proteins interacting with the components of T6SS and their role in positioning of T6SS assembly.

Call for proposal

ERC-2019-COG
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Funding Scheme

ERC-COG - Consolidator Grant

Host institution

UNIVERSITAT BASEL
Address
Petersplatz 1
4051 Basel
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 493 650

Beneficiaries (1)

UNIVERSITAT BASEL
Switzerland
EU contribution
€ 2 493 650
Address
Petersplatz 1
4051 Basel
Activity type
Higher or Secondary Education Establishments