Bacterial Type 6 secretion system
The Type 6 secretion system (T6SS) allows bacteria to deliver toxins into both eukaryotic and bacterial target cells causing disease or killing competitors. T6SS has several main parts, including a membrane complex, baseplate and long spring-like sheath wrapped around an inner tube. Sheath contraction generates energy to push the tube with toxins through the baseplate and membrane complex out of the cell. Direct contact with the target membrane and precise positioning of T6SS is required for efficient protein translocation. The EU-funded project AimingT6SS will investigate principles of spatial and temporal control of localisation of protein complexes to better understand how it allows bacteria to respond to external cues and interact with the environment. Researchers will study how bacteria sense attacks from other bacteria to dynamically reposition their T6SS. Genetic and biochemical approaches will characterise proteins interacting with the components of T6SS and their role in positioning of T6SS assembly.
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