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mARs: Mobile DNA driven antibiotic resistance spreading: molecular strategies, control and evolution for broad distribution

Project description

Following DNA on the move will shed light on its role in avoiding antibiotics

The structure and function of DNA and even the fact that not all DNA codes for proteins is arguably general knowledge by now. It has also been known to scientists for more than 50 years that some DNA sequences can move around in the genome, changing their number or location and often affecting the activity of nearby genes. Some estimates put these mobile DNA elements at nearly half of our genome. Increasing evidence supports a starring role of mobile genetic elements in antibiotic resistance via their ability to move themselves and associated resistance genes to new locations in the same or different DNA molecules in the same cell. However, the mechanisms are largely unknown. The EU-funded mARs project is applying bioinformatics and experimental approaches to shed light on the mechanisms and diversity of mobile DNA-related antimicrobial resistance.

Call for proposal

ERC-2019-COG
See other projects for this call

Host institution

UNIVERSITE DE GENEVE
Address
Rue Du General Dufour 24
1211 Geneve
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 899 118

Beneficiaries (2)

UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 1 899 118
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
EU contribution
€ 100 000
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations