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The dark side of evolution: the deleterious mutational landscape of RNA viruses

Project description

Deleterious mutations in the evolution of RNA viruses

Deleterious mutations have been under-studied in comparison to beneficial mutations since it has been technically unfeasible to sequence each deleterious mutation. Next-generation sequencing techniques have recently shown that a significant proportion of viral genetic diversity is a consequence of deleterious mutations. The EU-funded RNAVirFitness project investigates the distribution of fitness effects across a diverse array of RNA viruses, spanning representatives of each class of major human pathogens, both in vivo and in vitro. The project will explore how the accumulation of deleterious mutations may lead to the extinction of the viral population, and how this can be used as a novel strategy to tackle viral epidemics. Beyond their contribution to evolutionary biology, the results may be harnessed for the design of new vaccine strains and the development of broad-spectrum antiviral therapeutics.

Call for proposal

ERC-2019-STG
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Host institution

TEL AVIV UNIVERSITY
Address
Ramat Aviv
69978 Tel Aviv
Israel
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 495 625

Beneficiaries (1)

TEL AVIV UNIVERSITY
Israel
EU contribution
€ 1 495 625
Address
Ramat Aviv
69978 Tel Aviv
Activity type
Higher or Secondary Education Establishments