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Prevention of childhood Acute Lymphoblastic Leukemia immunology links oncology

Project description

Prevention of childhood acute lymphoblastic leukemia

Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer and it is a major cause of death in children aged 2–6 years in developed countries. One hypothesis is that an abnormal immune response to a common infection may be a trigger for ALL. The goal of the EU-funded PreventALL project is to analyse the postnatal genetic risk of B-cell-precursor (BCP)-ALL and to discover the mechanism by which exposure to infection causes BCP-ALL. The project team recently developed in vivo murine models with infection-dependent BCP-ALL. The project aims to investigate the synergy of genetic predisposition and exposure to infection in BCP-ALL as a proof of concept for the role of infection in precancerous disease, setting the starting point for the development of innovative leukemia prevention methods.

Host institution

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Net EU contribution
€ 1 217 925,00
Address
Ismaninger Strasse 22
81675 Muenchen
Germany

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Beneficiaries (2)

KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
Net EU contribution
€ 1 217 925,00
Address
Ismaninger Strasse 22
81675 Muenchen

See on map

Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TECHNISCHE UNIVERSITAET DRESDEN

Participation ended

Germany
Net EU contribution
€ 281 000,00
Address
Helmholtzstrasse 10
01069 Dresden

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Region
Sachsen Dresden Dresden, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00