Strain-stiffening synthetic vascular grafts
Cardiovascular diseases are leading causes of death, and appropriate treatment options remain challenging and expensive. Often, the only option is the replacement of native blood vessels. Patient-derived vascular grafts remain the gold standard as a replacement of the original vessel since currently available synthetic grafts have several drawbacks. The stress–strain curve in synthetic grafts is linear and the grafts are stiff in comparison to native blood vessels, which are soft and have a non-linear, strain-stiffening mechanical behaviour. The EU-funded VASCUGRAFT project aims to produce samples of biomimetic vascular grafts using previously developed materials that mimic the strain-stiffening of healthy native blood vessels.
Fields of science
Funding SchemeERC-POC-LS - ERC Proof of Concept Lump Sum Pilot
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