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Characterizing the roles of transcription factor isoforms in rewiring gene regulatory networks during adipogenesis

Project description

Transcription factor isoforms in adipogenesis

Fat tissue is a key site of metabolic regulation, and understanding how adipocytes develop is an important step in designing effective treatment and intervention strategies for metabolic disorders. Adipogenesis is regulated by a gene regulatory network (GRN) of successively activated transcription factors (TFs). Many of these TFs exist in distinct protein forms, so-called isoforms, and for some TFs, their isoforms have been shown to function differently from each other. The EU-funded FatTFIso project aims to study the extent to which the adipogenic GRN is modulated by TF isoforms. Findings from this project will improve our understanding of transcriptional mechanisms driving adipogenesis. The results will have broad implications for the role of TF isoforms in gene regulation, highlighting the complexity of the gene regulatory mechanisms that underlie cell and tissue specificity.

Call for proposal

H2020-MSCA-IF-2019
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Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
Address
Batiment Ce 3316 Station 1
1015 Lausanne
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 203 149,44