Transcription factor isoforms in adipogenesis
Fat tissue is a key site of metabolic regulation, and understanding how adipocytes develop is an important step in designing effective treatment and intervention strategies for metabolic disorders. Adipogenesis is regulated by a gene regulatory network (GRN) of successively activated transcription factors (TFs). Many of these TFs exist in distinct protein forms, so-called isoforms, and for some TFs, their isoforms have been shown to function differently from each other. The EU-funded FatTFIso project aims to study the extent to which the adipogenic GRN is modulated by TF isoforms. Findings from this project will improve our understanding of transcriptional mechanisms driving adipogenesis. The results will have broad implications for the role of TF isoforms in gene regulation, highlighting the complexity of the gene regulatory mechanisms that underlie cell and tissue specificity.
Call for proposal
See other projects for this call