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Deconstructing gene regulation through functional dissection of the 3D genome

Project description

Gene regulation and function of the 3D genome

The three-dimensional organisation of the genome inside the nucleus, referred to as the 3D genome (3DG), is crucial for gene regulation. The building blocks of the 3DG have been identified, but their contribution to gene regulation is not clear. The EU-funded FuncDis3D project aims to functionally dissect the 3DG to understand its effects on gene expression. The approach is to induce changes in the 3DG by acute protein depletion and evaluate these changes over time. The preliminary data show that by depleting regulators of the 3DG the changes occur within a few hours. Researchers will deplete a range of proteins in pluripotent and differentiated cells to determine their contribution to 3DG organisation. Simultaneous characterisation of the epigenome and transcriptome will allow them to determine the sequence of changes.

Host institution

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Net EU contribution
€ 1 997 425,00
Address
Plesmanlaan 121
1066 CX Amsterdam
Netherlands

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Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Non-EU contribution
€ 2 500,00

Beneficiaries (1)

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands
Net EU contribution
€ 1 997 425,00
Address
Plesmanlaan 121
1066 CX Amsterdam

See on map

Region
West-Nederland Noord-Holland Groot-Amsterdam
Activity type
Research Organisations
Non-EU contribution
€ 2 500,00