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Personalised Medicine for Intervertebral Disc Regeneration- Integrating Profiling, Predictive Modelling and Gene Activated Biomaterials

Project description

Personalised therapy for lower back pain

Lower back pain due to intervertebral disc (IVD) degeneration is a growing health concern in modern society. Although various biomaterial and cell-based therapies are undergoing clinical testing, it is unlikely that a 'one size fits all' approach will be effective given the distinct microenvironment of each IVD. The EU-funded INTEGRATE project proposes to combine in vitro screening and in silico modelling to design cell therapies based on the individual IVD profile and predict their regeneration outcome. The project will also develop gene-activated biomaterials that have the potential to regenerate the damaged IVD matrix and modulate inflammatory processes, opening new avenues for minimally invasive therapeutic strategies.

Host institution

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Net EU contribution
€ 1 754 543,00
Address
College Green Trinity College
D02 CX56 Dublin 2
Ireland

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Beneficiaries (2)

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
Ireland
Net EU contribution
€ 1 754 543,00
Address
College Green Trinity College
D02 CX56 Dublin 2

See on map

Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
Net EU contribution
€ 245 000,00
Address
Belfield
4 Dublin

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00