Interpreting the microbe-host dialogue
Host interactions with microorganisms (commensalism-symbiotic- pathogenic) is central for maintaining health and in influencing disease status. Both humans and bacteria produce key chemical signals known as oxylipins from the oxidation of fatty acids. In humans, oxylipins influence cell proliferation and chemotaxis and indeed immune responses. Oxylipins therefore serve as key regulators of inflammation. The EU-funded OMIT project is investigating the impact of microbially derived oxylipins (mOXY) on microbe-microbe interactions as well as on human physiology. Using state-of-the-art liquid chromatography-mass spectrometry technologies on biobanked samples from healthy volunteers and Crohn's disease patients, scientists will determine the role of mOXY in microbe-host and microbe-microbe interactions.