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Light-switchable proteins and Adhesion Micropatterns to Illuminate the Navigation machInery of Neurons

Project description

Profiling molecular traffic cops and the migrating cells they direct

Cell migration, either individually or in groups, occurs throughout embryonic development. Dysfunction of this process has been linked to numerous neurodevelopmental disorders as well as autism spectrum disorders and epilepsy. The traffic cops guiding migration are netrin molecules that can switch between attracting or repelling migrating cells, guiding their movement at intermediate checkpoints. This appears to be related to the type and number of netrin receptors at the tips of neuronal extensions, but the actual mechanisms are not clear. The EU-funded LAMININ project is planning to elucidate them through studies of the netrin-receptor complexes and the location and activity of proteins within neuronal growth cones on the move.

Call for proposal

H2020-MSCA-IF-2019
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Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
Address
Dr Molewaterplein 40
3015 GD Rotterdam
Netherlands

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Activity type
Higher or Secondary Education Establishments
EU contribution
€ 175 572,48