Light-switchable proteins and Adhesion Micropatterns to Illuminate the Navigation machInery of Neurons

Project description

Profiling molecular traffic cops and the migrating cells they direct

Cell migration, either individually or in groups, occurs throughout embryonic development. Dysfunction of this process has been linked to numerous neurodevelopmental disorders as well as autism spectrum disorders and epilepsy. The traffic cops guiding migration are netrin molecules that can switch between attracting or repelling migrating cells, guiding their movement at intermediate checkpoints. This appears to be related to the type and number of netrin receptors at the tips of neuronal extensions, but the actual mechanisms are not clear. The EU-funded LAMININ project is planning to elucidate them through studies of the netrin-receptor complexes and the location and activity of proteins within neuronal growth cones on the move.

Fields of science

• natural sciences › biological sciences › neurobiology
• medical and health sciences › basic medicine › neurology › epilepsy
• natural sciences › biological sciences › biochemistry › biomolecules › proteins
• natural sciences › biological sciences › developmental biology
• engineering and technology › other engineering and technologies › microtechnology › organ on a chip

Programme(s)

• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019
See other projects for this call

Funding Scheme

MSCA-IF-EF-RI - RI – Reintegration panel

Coordinator

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Address

Dr Molewaterplein 40
3015 GD Rotterdam
Netherlands

Activity type

Higher or Secondary Education Establishments

Links

EU contribution

€ 175 572,48