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A digestion and absorption mimicking bench-top intestinal model

Project description

An innovative in vitro assay for screening lipid-based drugs

Although oral drug administration is the preferred method of choice for both patients and healthcare providers, most drug candidates exhibit low solubility in a water-based environment such as the gut. To increase drug solubility, researchers have developed lipid-based formulations (LBFs), which, however, are difficult to characterise in vivo and incur high drug development costs. The EU-funded DINAMIC project is working on an efficient, rapid and cost-effective in vitro assay that mimics the gut microenvironment and can be used to screen LBFs. The assay setup provides an integrated, more physiologically relevant description of LBF performance and drug bioavailability in less than an hour. DINAMIC will develop an assay prototype and undertake activities towards its commercialisation.

Call for proposal

ERC-2019-PoC
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Funding Scheme

ERC-POC-LS - ERC Proof of Concept Lump Sum Pilot

Host institution

UPPSALA UNIVERSITET
Address
Von Kraemers Alle 4
751 05 Uppsala
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 150 000

Beneficiaries (1)

UPPSALA UNIVERSITET
Sweden
EU contribution
€ 150 000
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments