Investigating the role of the SIK3 gene in energy homeostasis
Obesity occurs as the result of an imbalance between food intake and energy expenditure. The EU-funded ObeSIK3 project will bring a new perspective to the understanding of obesity by studying a splice site mutation in the salt-inducible kinase 3 (SIK3) gene. This gene mutation is likely to disrupt energy homeostasis since mice with an exon 13 mutation of the SIK3 gene present an obese phenotype. To investigate how SIK3 affects energy homeostasis, the project will use virogenetic approaches in SIK3–exon 13 floxed mice and generate a neuron-specific mutant mice line for exon 13. Investigating what contributes to the pathophysiology of obesity increases the chances of finding efficient therapeutic targets for treating this major health issue.
Fields of science
- medical and health sciencesclinical medicinepsychiatrysleep disorders
- natural sciencesbiological sciencesneurobiology
- medical and health sciencesbasic medicinephysiologypathophysiology
- medical and health sciencesbasic medicinephysiologyhomeostasis
- medical and health scienceshealth sciencesnutritionobesity
Call for proposalSee other projects for this call
Funding SchemeMSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
15782 Santiago De Compostela
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
305 8577 Tsukuba Ibaraki
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