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Immune Safety Avatar: nonclinical mimicking of the immune system effects of immunomodulatory therapies

Project description

Research platform for safer immunomodulating therapy

Modulation of the immune system is emerging as an attractive approach for treating a plethora of conditions from immune-mediated diseases to cancer. However, responses in clinical trials have been variable, underscoring the need for better biomarkers, endpoints and monitoring approaches. Towards this goal, the EU-funded imSAVAR project will develop a platform for testing the safety and efficacy of immunomodulators. Researchers will work on novel assays, reliable models and predictive biomarkers to improve the safety of immunotherapy. In collaboration with big pharmaceutical companies, the ultimate goal of the imSAVAR effort is to transfer the knowledge from preclinical models into first-in-human studies.

Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Net EU contribution
€ 3 720 803,75
Address
Hansastrasse 27C
80686 Munchen
Germany

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 107 969,80

Participants (27)

UNIVERSITATSKLINIKUM JENA
Germany
Net EU contribution
€ 519 475,00
Address
Kastanienstr.1
07747 Jena

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Region
Thüringen Thüringen Jena, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 160 000,00
UNIVERSITEIT TWENTE
Netherlands
Net EU contribution
€ 519 362,50
Address
Drienerlolaan 5
7522 NB Enschede

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Region
Oost-Nederland Overijssel Twente
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
BIOSCI CONSULTING BVBA
Belgium
Net EU contribution
€ 288 750,00
Address
Weg Naar Geneuth 95
3631 Maasmechelen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Vlaams Gewest Prov. Limburg (BE) Arr. Tongeren
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
Net EU contribution
€ 419 687,50
Address
Albinusdreef 2
2333 ZA Leiden

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Region
West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAET LEIPZIG
Germany
Net EU contribution
€ 706 775,00
Address
Ritterstrasse 26
04109 Leipzig

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Region
Sachsen Leipzig Leipzig
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
Net EU contribution
€ 568 650,00
Address
Carl-neuberg-strasse 1
30625 Hannover

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Region
Niedersachsen Hannover Region Hannover
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Germany
Net EU contribution
€ 724 250,00
Address
Geschwister-scholl-platz
72074 Tuebingen

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Region
Baden-Württemberg Tübingen Tübingen, Landkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 152 030,20
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
Net EU contribution
€ 366 485,00
Address
Christoph Probst Platz 1
6020 Innsbruck

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Region
Westösterreich Tirol Innsbruck
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
BUNDESINSTITUT FUR IMPFSTOFFE UND BIOMEDIZINISCHE ARZNEIMITTEL
Germany
Net EU contribution
€ 602 556,25
Address
Paul-ehrlich-strasse 51-59
63225 Langen

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Region
Darmstadt Offenbach, Landkreis
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Non-EU contribution
€ 0,00
INFORMATION TECHNOLOGY FOR TRANSLATIONAL MEDICINE (ITTM) SA
Luxembourg
Net EU contribution
€ 340 000,00
Address
27 Rue Henri Koch
4354 Esch Sur Alzette

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Luxembourg Luxembourg Luxembourg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITE DU LUXEMBOURG
Luxembourg
Net EU contribution
€ 423 400,00
Address
2 Avenue De L'universite
4365 Esch-sur-alzette

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Region
Luxembourg Luxembourg Luxembourg
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
Net EU contribution
€ 978 100,00
Address
Josef-schneider-strasse 2
97080 Wurzburg

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Region
Bayern Unterfranken Würzburg, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
LUNDS UNIVERSITET
Sweden
Net EU contribution
€ 396 771,25
Address
Paradisgatan 5C
22100 Lund

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Region
Södra Sverige Sydsverige Skåne län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
T-CURX GMBH
Germany
Net EU contribution
€ 211 250,00
Address
Friedrich-bergius-ring 15
97076 Wurzburg

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Unterfranken Würzburg, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITETET I OSLO
Norway
Net EU contribution
€ 124 250,00
Address
Problemveien 5-7
0313 Oslo

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Region
Norge Oslo og Viken Oslo
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
DYNAMIC42 GMBH
Germany
Net EU contribution
€ 88 750,00
Address
Winzerlaer Str 2
07745 Jena

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Thüringen Thüringen Jena, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
BLUEBIRD BIO INC.

Participation ended

United States
Net EU contribution
€ 0,00
Address
60 Binney Street
02142 Cambridge Ma

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
LABCORP EARLY DEVELOPMENT LABORATORIES LIMITED
United Kingdom
Net EU contribution
€ 0,00
Address
Otley Road
HG3 IPY Harrogate

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Region
Yorkshire and the Humber North Yorkshire North Yorkshire CC
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 2 160 000,00
BOEHRINGER INGELHEIM INTERNATIONALGMBH
Germany
Net EU contribution
€ 0,00
Address
Binger Strasse
55218 Ingelheim

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 028 750,00
JDRF INTERNATIONAL
United States
Net EU contribution
€ 0,00
Address
26 Broadway 14Th Floor
10004 New York

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Activity type
Research Organisations
Non-EU contribution
€ 105 000,00
MERCK KOMMANDITGESELLSCHAFT AUF AKTIEN
Germany
Net EU contribution
€ 0,00
Address
Frankfurter Strasse 250
64293 Darmstadt

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Region
Darmstadt Darmstadt, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 570 000,00
NOVARTIS PHARMA AG
Switzerland
Net EU contribution
€ 0,00
Address
Lichtstrasse 35
4056 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 920 000,00
F. HOFFMANN-LA ROCHE AG
Switzerland
Net EU contribution
€ 0,00
Address
Grenzacherstrasse 124
4070 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 600 000,00
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
Net EU contribution
€ 0,00
Address
Pierre Brossolette 1
91380 Chilly Mazarin

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Region
Ile-de-France Ile-de-France Essonne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 247 746,00
INSTITUT DE RECHERCHES SERVIER
France
Net EU contribution
€ 0,00
Address
3 Rue De La Republique
92150 Suresnes

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Region
Ile-de-France Ile-de-France Hauts-de-Seine
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 840 000,00
TRANSGENE SA
France
Net EU contribution
€ 0,00
Address
Boulevard Gonthier D Andernach Parc D Innovation
67400 Illkirch-graffenstaden

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Region
Grand Est Alsace Bas-Rhin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 120 000,00
MERCK SHARP & DOHME CORP
United States
Net EU contribution
€ 0,00
Address
One Merck Drive
08889 Whitehouse Station Nj

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 740 000,00