New insight into blood clotting: implications for thrombosis treatment?
Cardiovascular disease, the leading cause of death worldwide, often leads to myocardial infarction and ischemic stroke due to occlusive thrombus formation. Blood clotting is a complex process that involves many different cell types and factors. Scientists of the EU-funded PAELLA project propose to study the role of the newly identified platelet receptor PEAR1 on haemostasis, inflammation and thrombosis. Through state-of-the-art methodologies, they will activate the receptor and study its impact on platelets, testing the hypothesis that PEAR1 drives thrombo-inflammatory disease in the vasculature. The work will unveil novel aspects in the blood clotting process and may lead to new treatment strategies to combat thrombosis.
Fields of science
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