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Active role of skeletal muscle extracellular matrix in muscular dystrophies

Project description

Muscular dystrophies: the role of the extracellular matrix

Muscular dystrophies (MD) are a group of genetic disorders associated with weakness and progressive loss of muscle. MDs are primarily caused by defects in the trans-membrane dystroglycan protein complex, a structural and functional bridge between the myofiber contractile apparatus and the extracellular matrix (ECM). The key objective of the EU-funded DYSTROPHIC-ECM project is to identify ECM alterations associated with MD. For this purpose, researchers will analyse ECM composition using proteomics in different mouse models of MD. The project will also explore how ECM alterations affect various processes paramount for MD pathophysiology such as myogenesis, angiogenesis and fibrosis.

Call for proposal

H2020-MSCA-IF-2019
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Coordinator

UNIVERSITE LYON 1 CLAUDE BERNARD
Address
Boulevard Du 11 Novembre 1918 Num43
69622 Villeurbanne Cedex
France
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 295 061,76