Finding a balance in the treatment of insulin deficiency
Insulin deficiency (ID) is a life-threatening condition caused by pancreatic β cell loss. Untreated ID is a lethal catabolic disease characterised by hyperglycaemia. In addition to increased circulating glucose levels, β cell loss leads to several other complications that are also life-threatening (severe hyperketonaemia and ketoacidosis). It is therefore important to develop ID treatment strategies that improve hyperglycaemia while reducing the risks of other defects caused by ID. Patients on insulin therapy are at increased risk for developing kidney failure, blindness, nerve damage, heart attack, stroke and hypoglycaemia. The goal of the EU-funded LifeWithoutInsulin project is to develop treatment compositions that reduce the amount of insulin dosage and the risks associated with insulin therapy.
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