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GOOD OR BAD BUGS, FRIEND OR FOES: UNRAVELING DIFFERENCES BETWEEN MUTUALISM AND PATHOGENICITY IN BURKHOLDERIA SPECIES

Project description

The genus Burkholderia: friends or foes?

Bacteria of the genus Burkholderia exhibit different ways of interacting with the host, such as mutualism, commensalism or pathogenicity. Although certain species are beneficial to plants, others, such as B. cenocepacia, cause severe infections in cystic fibrosis and immunocompromised patients. The scope of the EU-funded GOOD OR BAD BUGS project is to investigate the dissimilarities between the beneficial and the pathogenic Burkholderia species. Researchers are working under the hypothesis that genomic differences are the ones that dictate host colonisation and interaction. Using the high-throughput genetic screening method of transposon-sequencing, they will identify genes associated with bacterial fitness in a particular environment. The project's results have important implications for both agriculture and medicine.

Coordinator

UNIVERSITAT ZURICH
Net EU contribution
€ 191 149,44
Address
Ramistrasse 71
8006 Zurich
Switzerland

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00