INTER-REGULATION OF CIRCADIAN AND AUTOPHAGIC PROCESSES IN STEM CELLS: IMPACT ON TISSUE REGENERATION AND AGING

Project description

The impact of ageing on stem cell regenerative potential

Tissue regeneration is facilitated by quiescent resident stem cells that become activated upon injury or the need to replace tissue-specific cells. Accumulating evidence indicates that with ageing, muscle stem cells known as satellite cells (SCs) lose their regenerative capacity, decrease autophagy and reprogram their circadian transcriptome. With this in mind, scientists of the EU-funded CIRCautophAGING project will investigate the mechanisms required to preserve stem cell regenerative fitness throughout life. They are working under the hypothesis that SC fitness is driven by an interplay between active autophagy and circadian regulation. Using transgenic animals, they will provide fundamental knowledge on stem cell biology and ageing, opening new avenues for regenerative therapies.

Fields of science

• engineering and technology › mechanical engineering › vehicle engineering › aerospace engineering › satellite technology
• natural sciences › biological sciences › cell biology
• medical and health sciences › medical biotechnology › cells technologies › stem cells

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

UNIVERSIDAD POMPEU FABRA

Net EU contribution

€ 160 932,48

Address

Placa De La Merce, 10-12
08002 Barcelona
Spain

Region

Este › Cataluña › Barcelona

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00