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Histone modifying enzymes as direct regulators of metabolic reprogramming: Towards a New Paradigm

Project description

The link between epigenetics and metabolism

Accumulating evidence indicates that epigenetics plays a central role in regulating metabolic gene expression. Scientists of the EU-funded MetabolACE project are interested in the mechanism by which histone modifying enzymes impact metabolism. Their hypothesis is that these enzymes consume large amounts of key metabolites and thus drive metabolic rewiring by altering their abundance. Using a combination of epigenetics and metabolomics techniques, researchers will investigate how histone acetyltransferase (HAT) activity affects the pool of acetyl coenzyme A (Acetyl-CoA) in cells. The work will establish a new fundamental link between epigenetics and metabolism in both health and disease.

Coordinator

UNIVERSITY OF CYPRUS
Net EU contribution
€ 145 941,12
Address
Avenue Panepistimiou 2109 Aglantzi
1678 Nicosia
Cyprus

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Region
Κύπρος Κύπρος Κύπρος
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00