Histone modifying enzymes as direct regulators of metabolic reprogramming: Towards a New Paradigm

Project description

The link between epigenetics and metabolism

Accumulating evidence indicates that epigenetics plays a central role in regulating metabolic gene expression. Scientists of the EU-funded MetabolACE project are interested in the mechanism by which histone modifying enzymes impact metabolism. Their hypothesis is that these enzymes consume large amounts of key metabolites and thus drive metabolic rewiring by altering their abundance. Using a combination of epigenetics and metabolomics techniques, researchers will investigate how histone acetyltransferase (HAT) activity affects the pool of acetyl coenzyme A (Acetyl-CoA) in cells. The work will establish a new fundamental link between epigenetics and metabolism in both health and disease.

Fields of science

• natural sciences › chemical sciences › analytical chemistry › mass spectrometry
• natural sciences › biological sciences › genetics › genomes
• natural sciences › biological sciences › biochemistry › biomolecules › proteins › enzymes
• natural sciences › biological sciences › genetics › epigenetics

Programme(s)

• H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme
• H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility

Topic(s)

• MSCA-IF-2019 - Individual Fellowships

Call for proposal

H2020-MSCA-IF-2019

See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

UNIVERSITY OF CYPRUS

Net EU contribution

€ 145 941,12

Address

Avenue Panepistimiou 2109 Aglantzi
1678 Nicosia
Cyprus

Region

Κύπρος › Κύπρος › Κύπρος

Activity type

Higher or Secondary Education Establishments

Links

Other funding

€ 0,00