Project description
The link between epigenetics and metabolism
Accumulating evidence indicates that epigenetics plays a central role in regulating metabolic gene expression. Scientists of the EU-funded MetabolACE project are interested in the mechanism by which histone modifying enzymes impact metabolism. Their hypothesis is that these enzymes consume large amounts of key metabolites and thus drive metabolic rewiring by altering their abundance. Using a combination of epigenetics and metabolomics techniques, researchers will investigate how histone acetyltransferase (HAT) activity affects the pool of acetyl coenzyme A (Acetyl-CoA) in cells. The work will establish a new fundamental link between epigenetics and metabolism in both health and disease.
Fields of science
Programme(s)
Funding Scheme
MSCA-IF-EF-ST - Standard EF
Coordinator
1678 Nicosia
Cyprus
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