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Exploring molecular determinants of charged disordered protein interactions, phase separation and function from the test-tube to the cell

Project description

Insight into the complex nature of disordered proteins

Intrinsically disordered proteins (IDPs) are a family of proteins that lack persistent 3D structure. They constitute up to 40 % of the proteome and participate in the formation of liquid–liquid phase separation (LLPS) driven assemblies that facilitate numerous biochemical interactions. The EU-funded DisCharge project aims to study two regulators of chromatin structure and function, the nucleosome binding linker histone (H1) and its nuclear chaperone prothymosin-alpha (ProTa). Researchers will probe the interaction between these two proteins and study the impact on heterochromatin assembly formation, which leads to transcriptional regulation. Results will shed light on the factors that drive the behaviour and function of this intriguing class of proteins.

Coordinator

UNIVERSITAT ZURICH
Net EU contribution
€ 191 149,44
Address
Ramistrasse 71
8006 Zurich
Switzerland

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00